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Cardiovascular Risk in Patients with Chronic Kidney Disease
who responded to combined therapy with ACE inhibitors and epoetin with following successful renal transplantation. This picture probably reflects
a regression of LVH showed a greater survival rate in long-term follow-up the synergistic action of ‘traditional risk factors’ whose expression is
than subjects with persisting LVH.
36
Similar behaviour was shown for heart increased in renal disease, and emerging factors that are specific to CKD
disease (HD) patients with concentric LVH, who responded with an LVH and particularly to ESRD. An early multifactorial intervention aimed at
regression to a prolonged course of ACE inhibitors, and whose long-term controlling arterial hypertension, anaemia, Ca-P metabolism
incidence of non-fatal CV events was lower than that of eccentric LVH
patients unresponsive to such a treatment.
37
The risk of unfavourable cardiovascular
A reduction of the risk of CV death at five years was observed in renal
prognosis increases as renal insufficiency
transplant recipients on cyclosporine undergoing active treatment of
dyslipidaemia with fluvastatine compared with placebo.
38
Lastly, a
progresses towards end-stage renal
recent retrospective analysis of more than 2,000 renal transplant
disease (ESRD), reaches its maximum in
recipients in Austria showed a better survival rate for patients who had
undergone renin-angiotensin blockade with either ACE inhibitors or
ESRD and persists following successful
angiotenin receptor blocker (ARB),
39
although a more recent analogous
renal transplantation.
retrospective analysis evaluating data from the European Transplant
Registry did not confirm this observation in a larger population sample.
40
abnormalities and all of the putative risk factors involved in the high
Conclusions prevalence of CVD of renal patients should be the most advisable
The risk of unfavourable CV prognosis increases as renal insufficiency strategy for offsetting this dismal situation and improving the general
progresses towards ESRD, reaches its maximum in ESRD and persists and CV prognosis of patients suffering from renal disease. ■
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