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Aesthetic Dermatology
have similar beneficial effects on aged and photoaged skin, those that
have been intensely studied have minimal effects on the dermal Yolanda Rosi Helfrich is an Assistant Professor in the
extracellular matrix, and it is questionable whether they have clinical
Department of Dermatology at the University of
Michigan. She serves as Co-Director of the Programme
effects.
36
Finally, the use of dermal fillers, specifically cross-linked
for Clinical Research in Dermatology. Her clinical
hyaluronic acid, has been demonstrated to result in increased collagen research focuses on ageing skin, antioxidant therapy for
production and downregulation of MMPs, presumably by stretching
ageing skin, rosacea and clinical trials. Dr Helfrich
graduated from the University of Michigan Medical
the fibroblasts and resulting in increased mechanical tension within
School and completed her residency in dermatology
the dermal matrix.
37
This may explain the clinical observation that at the University of Michigan.
individuals who regularly receive injections with these fillers seem to
have more sustained effects over time, and may require less frequent
Dana L Sachs is an Associate Professor of
Dermatology at the University of Michigan. She serves
injections as time passes.
as Co-Director of the Programme for Clinical Research
in Dermatology. Dr Sachs received her medical degree
Conclusion
from Boston University and completed an internship
in internal medicine at Beth Israel Hospital in Boston.
In summary, certain key molecular pathways underlie both photoageing
After spending five years at Memorial Sloan-Kettering
and intrinsic chronological skin ageing. Evidence suggests that
Cancer Center in New York, she returned to the
oxidative stresses, in the form of either UV irradiation or the
University of Michigan, where her practice focuses on
medical and cosmetic dermatology.
accumulation of ROS with increasing age, are the inciting events that
activate these pathways. The end result in both processes is decreased
John J Voorhees is the Duncan and Ella Poth
collagen production and increased collagen breakdown. Continued
Distinguished Professor at the University of Michigan
research into antioxidants that could mitigate the effects of these
Medical School in Ann Arbor, where he is Chairman of
the Department of Dermatology. Professor Voorhees
oxidative stresses may lead to the development of additional
divides his time among medical research, patient care,
preventative therapies. The identification of additional therapies that
education of medical students and physicians training
can lead to the upregulation of collagen production or can prevent
to become dermatologists and chairing the department.
His research focuses on psoriasis and premature ageing
collagen breakdown could add to our treatment armamentarium,
of the skin.
enabling us to treat these two ubiquitous processes. ■
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42 EUROPEAN DERMATOLOGY
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