Boehringer_ad.qxp 28/7/08 3:09 pm Page 7
NEARLY 2 HOURS MORE “ON” TIME
WITH MIRAPEX PLUS LEVODOPA
1
(What a bargain for Joe)
In advanced PD
MIRAPEX improves activities of daily living (ADL) and motor
scores when added to levodopa
1-4
MIRAPEX increased daily “on” time
*
by nearly 2 hours
1
…
110
MIRAPEX + levodopa
100
90
102 min
Levodopa + placebo
80
70
60
50
Pinter MM, Pogarell O, Oertel WH. Efficacy,
Minutes
40 safety, and tolerance of the non-ergoline
30
dopamine agonist pramipexole in the
20
treatment of advanced Parkinson’s disease:
a double blind, placebo controlled,
10
0
“On” time
randomised, multicentre study. J Neurol
-10
“Off” time
Neurosurg Psychiatry. 1999;66:436-441.
17 min Objective: Assess MIRAPEX as an add-on
-20
drug in patients with advanced PD.
…and reduced “off” time
†
by 31%
2
35
MIRAPEX + levodopa
30
31%
Levodopa + placebo
25
p <0.001
20
eduction
Lieberman A, Ranhosky A, Korts D. Clinical
15
evaluation of pramipexole in advanced
Parkinson’s disease: results of a double-blind,
Mean % r
10
placebo-controlled, parallel-group study.
Neurology. 1997;49:162-168.
5
7%
Objective: Assess motor functioning, safety,
and tolerability in advanced PD patients
0
taking MIRAPEX.
* “On” times are periods when a patient is responding well to medication.
† “Off” times are when a patient experiences partial or total return of PD
symptoms despite having therapeutic levels of treatment in the body.
For more information, visit: www.mirapex.com/pd
Copyright © 2008, Boehringer Ingelheim Pharmaceuticals, Inc. All rights reserved.
(05/08) MP53655
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