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Infertility and Assisted Reproduction
common, complex diseases, such as asthma, cancer, diabetes, heart disease, powerful research tools for identifying genetic variants that contribute to
and mental illnesses. health and disease.
Whole genome information, when combined with clinical and other The spectrum of POI is a disorder that should be amenable to this
phenotype data, offers the potential for increased understanding of basic scientific approach. The author’s group is in the process of developing a
biological processes affecting human health, improvement in the POI consortium through which samples will be acquired for this purpose.
On October 28, 2007, the NIH released a new policy on genome-wide
association studies that applies to any such studies initiated after January
A research consortium of diverse
25, 2008. The policy fosters data-sharing while protecting research
participants’ and researchers’ rights to publish and maintain IP. The policy
expertise with a mission of uncovering creates a centralized NIH genome-wide association study data repository.
the autoimmune and genetic mechanisms
Researchers who share will have access to other researchers’ data for
their own research. The direct link to the policy can be found at
of primary ovarian insufficiency would grants.nih.gov/grants/guide/notice-files/NOT-OD-07-088.html
likely provide the most direct path to
Conclusions
such markers. Social trends in delayed childbearing combined with advances in
reproductive technology that extend fertility in women are working
together to create a huge market opportunity. There is a critical need for
prediction of disease and patient care, and ultimately the realization of validated markers that can inform young women of their functional ovarian
the promise of personalized medicine. In addition, rapid advances in age. A research consortium of diverse expertise with a mission of
understanding the patterns of human genetic variation and maturing uncovering the autoimmune and genetic mechanisms of POI would likely
high-throughput, cost-effective methods for genotyping are providing provide the most direct path to such markers. ■
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48 US OBSTETRICS & GYNECOLOGY
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