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Contents
Advisory Panel
5
Foreword
6
Luigi D Notarangelo
Chair, Paediatric Immunology Research, and Professor of Paediatrics and Pathology, Harvard Medical School
Editor’s Choice
7
Snake Venom and Haemostasis – An Overview
Ponlapat Rojnuckarin
Head, Division of Haematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University
Coagulation Disorders
Awareness of Mild Bleeding Disorders 12
Pieter W Kamphuisen
Department of Vascular Medicine, Academic Medical Centre, Amsterdam
Haemophilia
Inhibitors in Haemophilia A – Ongoing Research and Clinical Practice 14
Wolfhart Kreuz,
1
Carmen Escuriola-Ettingshausen
1
and Günter Auerswald
2
1. Centre of Paediatrics III, Department of Haematology, Oncology and Haemostaseology, Johann-Wolfgang-Goethe
University Hospital, Frankfurt; 2. Prof.–Hess Children’s Hospital, Klinikum Bremen-Mitte, Bremen
Haemophilia Treatment – Current and Future Challenges 21
J Blatny˘,
1
J Ingerslev,
2
A Huth-Kühne,
3
T Lambert
4
and J Windyga
5
1. Children’s University Hospital, Brno; 2. Aarhus University; 3. Kurpfalzkrankenhaus Hemophilia Centre,
Heidelberg; 4. Assistance Publique, Hôpitaux de Paris; 5. Institute of Transfusion Medicine, Warsaw
Immunological Aspects of Inhibitor Development in Haemophilia 28
David Keeling
1
and Cindy Lee
2
1. Consultant Haematologist, Oxford Radcliffe Hospitals, and Honorary Senior Clinical Lecturer
in Haematology, University of Oxford; 2. Staff Medical Writer, Touch Briefings
von Willebrand Disease
Long-term Prophylaxis in von Willebrand Disease –
How Should It Be Given and for Whom? 34
Erik Berntorp, Sharyne M Donfield and Thomas C Abshire
The von Willebrand Disease Prophylaxis (VIP) Study Group
Current Management of von Willebrand Disease 38
Augusto B Federici
Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Department of Medicine and
Medical Specialities, IRCCS Maggiore Policlinico Hospital, Mangiagalli
Platelet Disorders
Congenital Disorders of Platelet Function 43
Gian Marco Podda, Mariateresa Pugliano and Marco Cattaneo
San Paolo Hospital, Department of Medicine, Surgery and Dentistry, University of Milan
Romiplostim – A Thrombopoiesis-stimulating Peptibody for the
Management of Chronic Immune Thrombocytopenic Purpura in Adults 48
Adrian Newland
Professor of Haematology, Barts and the London NHS Trust
Thrombosis
Management Based on Residual Vein Thrombosis to Optimise the
Duration of Oral Anticoagulants After Deep Vein Thrombosis 52
Sergio Siragusa
Haematology Department, University Hospital of Palermo
Defective Fibrinolysis and Genetic or Acquired Pro-coagulant
Changes Synergistically Increase the Risk of Venous Thrombosis 55
Mirjam E Meltzer,
1,2
Frits R Rosendaal
2
and Ton Lisman
1,3
1. Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht;
2. Department of Clinical Epidemiology, Leiden University Medical Centre; 3. Surgical Research Laboratory,
Department of Surgery, University Medical Centre Groningen, University of Groningen
EUROPEAN HAEMATOLOGY 3
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