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22q11.2 Deletion Syndrome and Schizophrenia in Children and Adolescents
multifactorial account that outlines the different routes psychosis- psychotic symptoms in youths with 22q11DS but help to prevent their
proneness may employ in the unfolding of clinically relevant psychotic development into clinical states of psychosis. ■
phenomena. We feel that the high prevalence of schizophrenia in
22q11DS is best represented by the wealth of risk factors associated Acknowledgements
with the neurogenetic syndrome in terms of genetic, neuroanatomical, Important thanks go to the Swiss and French 22q11DS parent
cognitive and affective concerns. Clearly, more investigations associations, Connect22 and Generation 22, without which this article
concerning the multiple risk-factor interactions are necessary, some of would not have been possible. We also wish to thank Bronwyn Glaser
which may investigate complex processes such as brain maturation and Marie Schaer for their ongoing collaboration and contributions.
and the unfolding of hallucinations, while others further examine This research process was supported by research grants to Stephan
higher-order cognitive functions such as social cognition in relation to Eliez from the Swiss National Fund for Research (PP00B-102864), the
the elaboration of a delusional belief system. These may yield NARSAD Foundation (2002 Lieber Investigator Award) and the
preventative treatment strategies that acknowledge the expression of Academic Society of Geneva.
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