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Unrelated Transplants for High-risk Adult Acute Lymphoblastic Leukaemia
allogeneic hematopoietic stem-cell transplantation in adult 4226–35. 2 partially HLA-matched umbilical cord units to enhance
patients with acute lymphoblastic leukemia: No difference 32. Fielding AK, Richards SM, Chopra R, et al., Outcome of 609 engraftment in adults with hematological malignancy, Blood,
in related compared with unrelated transplant in first adults after relapse of acute lymphoblastic leukemia (ALL); 2005;105:1343–7.
complete remission, J Clin Oncol, 2004;22:2816–25. an MRC UKALL12/ECOG 2993 study, Blood, 2007;109: 51. Bachanova V, Verneris MR, DeFor T, et al., Prolonged
15. Singhai S, Henslee-Downey PJ, Powles R, et al., 944–50. survival in adults with acute lymphoblastic leukemia after
Haploidentical versus autologous hematopoietic stem cell 33. Espérou H, Boiron JM, Cayuela JM, et al., A potential graft- reduced-intensity conditioning with cord blood or sibling
transplantation in patients with acute leukemia beyond first versus-leukemia effect after allogeneic hematopoietic stem donor transplantation, Blood, 2009;113:2902–5.
remission, Bone Marrow Transplant, 2003;31:889–95. cell transplantation for patients with Philadelphia 52. Magro E, Regidor C, Cabrera R, et al., Early hematopoietic
16. Ottinger HD, Ferencik S, Beelen DW, et al., Hematopoietic chromosome-positive acute lymphoblastic leukemia: recovery after single unit unrelated cord blood
stem cell transplantation: contrasting the outcome of results from the French Bone Marrow Transplantation transplantation in adults supported by co-infusion of
transplantations from HLA-identical sibling, partially HLA- Society, Bone Marrow Transplant, 2003;31:909–18. mobilized stem cells from a third party donor, Haematologica,
mismatched related donors, and HLA-matched unrelated 34. Garderet L, Labopin M, Gorin NC, et al., Patients with acute 2006;91:640–48.
donors, Blood, 2003;102:1131–7. lymphoblastic leukaemia allografted with a matched 53. Barker J, Weisdorf DJ, DeFor TE, et al., Transplantation of 2
17. Sanz GF, Saavedra S, Planelles D, et al., Standarized, unrelated donor may have a lower survival with a partially HLA-matched umbilical cord units to enhance
unrelated donor cord blood transplantation in adults with peripheral blood stem cell graft compared to bone marrow, engraftment in adults with hematologic malignancy, Blood,
hematologic malignancies, Blood, 2001;98:2332–8. Bone Marrow Transplant, 2003;31:23–9. 2005;105:1343–47.
18. Rocha V, Labopin M, Sanz G, et al., Transplants of umbilical- 35. Eapen M, Rubinstein P, Zhang MJ, et al., Outcome of 54. Frassoni F, Gualandi F, Podestà M, et al., Direct intrabone
cord blood or bone marrow from unrelated donors in transplantation of unrelated donor umbilical cord blood and transplant of unrelated cord-blood cells in acute leukaemia:
adults with acute leukaemia, N Eng J Med, 2004;351:2276–85. bone marrow in children with acute leukaemia: a a phase I/II study, Lancet Oncol, 2008;9:831–9.
19. Laughlin MJ, Eapen M, Rubinstein P, et al., Outcomes after comparison study, Lancet, 2007;369:1947–54. 55. Brunstein CG, Barker JN, Weisdorf DJ, et al., Intra-BM
transplantation of cord blood or bone marrow from 36. Bornhäuser M, Theuser C, Soucek S, et al., Allogeneic injection to enhance engraftment after myeloablative
unrelated donors in adults with leukaemia, N Eng J Med, transplantation of G-CSF mobilized peripheral blood stem umbilical cord blood transplantation with two partially HLA-
2004;351:2265–75. cell from unrelated donors: a retrospective analysis, matched units, Bone Marrow Transplant, 2009 (Epub ahead of
20. Takahashi S, Iseki T, Ooi J, et al., Single-institute comparative Haematologica, 2000;85:839–47. print).
analysis of unrelated bone marrow transplantation and 37. Marks DI, Pérez WS, He W, et al., Unrelated donor 56. Granados E, De La Camara R, Madero L, et al.,
cord blood transplantation for adult patients with transplants in adult patients with Philadelphia-negative Hematopoietic cell transplantation in acute lymphoblastic
hematologic malignancies, Blood, 2004;104: 3813–20. acute lymphoblastic leukemia in first complete remission, leukaemia: better long-term event-free survival with
21. Takahashi S, Ooi J,T Tomonari A, et al., Comparative single- Blood, 2008;112:426–34. conditioning regimens containing total body irradiation,
institute analysis of cord blood transplantation from 38. Flomenberg N, Baxter-Lowe LA, Confer D, et al., Impact of Hematologica, 2000;85:1060–67.
unrelated donors with bone marrow or peripheral blood HLA class I and class II high-resolution on outcomes of 57. Davies SM, Ramsay NKC, Klein JPK, et al., Comparison of
stem-cell transplantats from related donors in adult unrelated donor bone marrow transplantation: HLA-C preparative regimens in transplants for children with acute
patients with hematologic malignancies after myeloablative mismatching is associated with a strong adverse effect on lymphoblastic leukemia, J Clin Oncol, 2000;18:340–47.
conditioning regimen, Blood, 2007;109:1322–30. transplantation outcome, Blood, 2004;104:1923–30. 58. Hartman AR, Williams SF, Dillon JJ, Survival, disease-free
22. Lee S, Cho BS, Kim SY, et al., Allogeneic stem cell 39. Petersdorf EW, Anasetti C, Martin PJ, et al., Limits of HLA survival and adverse effects of conditioning for allogeneic
transplantation in first complete remission enhances graft- mismatching in unrelated hematopoietic cell bone marrow transplantation with busulfan/
versus leukemia effect in adults with acute lymphoblastic transplantation, Blood,. 2004;104:2976–80. cyclophosphamide vs total body irradiation: a meta-
leukemia: Antileukemic activity of chronic graft-versus host 40. Rubinstein P, Carrier C, Scaradavou A, et al., Outcomes analysis, Bone Marrow Transplant, 1998;22:439–43.
disease, Biol Blood Marrow Transplant, among 562 recipients of placental-blood transplants from 59. Martino R, Giralt S, Caballero MD, et al., Allogeneic
2007;13:1083–94. unrelated donors, N Engl J Med, 1998;339:1565–77. hematopoietic stem cell transplantation with reduced-
23. Dahlke J, Kröger N, Zabelina T, et al., Comparable results in 41. Kögler G, Enczmann J, Rocha V, et al., High-resolution HLA intensity conditioning in acute lymhpblastic leukemia: a
patients with acute lymphoblastic leukemia after related typing by sequencing for HLA-A, -B, -C, -DR, -DQ in 122 feasibility study, Haematologica, 2003;88:555–60.
and unrelated stem cell transplantation, Bone Marrow unrelated cord blood/patient pair transplants hardly 60. Mohty M, Labopin M, Tabrizzi R, et al., Reduced intensity
Transplant, 2006;37:155–63. improves long-term clinical outcome, Bone Marrow Transplant, conditioning allogeneic stem cell transplantation for adult
24. Ringdén O, Pavletic SZ, Anassetti C, et al., The graft-versus 2005;36:1033–41. patients with acute lymphoblastic leukemia: a retrospective
leukemia effect using matched unrelated donors is not 42. Barker J, Davies S, DeFor T, et al., Survival after study from the European Group for Blood and Marrow
superior to HLA-identical siblings for hematopoietic stem transplantation of unrelated donor umbilical cord blood is Transplantation, Haematologica, 2008;93:303–6.
cell transplantation, Blood, 2009;113:3110–18. comparable of that of human leukocyte antigen-matched 61. Schoemans H, Theunissen K, Maertens J, et al., Adult
25. Fielding AK, Rowe JM, Richards SM, et al., Prospective unrelated donor bone marrow: results of a matched-pair umbilical cord blood transplantation: a comprehensive
outcome data on 267 unselected adult patients with analysis, Blood, 2001;97:2957–61. review, Bone Marrow Transplant, 2006;38:83–93.
Philadelphia chromosome positive acute lymphoblastic 43. Rocha V, Cornish J, Sievers EL, et al., Comparison outcomes 62. Hale G, Jacobs P, Wood L, et al., CD52 antibodies for
leukaemia confirms superiority of allogeneic transplant of unrelated bone marrow and umbilical cord transplants in prevention of graft-versus-host disease and graft rejection
over chemotherapy in the pre-imatinib era: Results from children with acute leukemia, Blood, 2001; 97:2962–71. following transplantation of allogeneic peripheral blood
the international ALL trial MRC UKALLXII/ECOG2993, Blood, 44. Eapen M, Logan BR, Confer DL, et al., Peripheral blood stem cells, Bone Marrow Transplant, 2000;26:69–76.
2009;113(19):4489–96. grafts from unrelated donors are associated with increased 63. Zikos P, Van Lint MT, Lamparelli T, et al., Allogeneic
26. Mortuza FY, Papaioannou M, Moreira MI, et al., Minimal acute and chronic graft-versus-host disease without hemopoietic stem cell transplantation for patients with high
residual disease tests provide an independent predictor of improved survival, Biol Blood Marrow Transplant, risk acute lymphoblastic leukemia: favorable impact of
clinical outcome in adult acute lymphoblastic leukemia, 2007;13:1461–8. chronic graft-versus-host disease on survival and relapse,
J Clin Oncol, 2002;20:1094–1104. 45. Atsuta Y, Suzuki R, Nagamura-Inoue T, et al., Disease- Haematologica, 1998;83:896–903.
27. Bruggermann M, Raff, Flohr T, et al., Clinical significance of specific analyses of unrelated cord blood transplant 64. Grigg AP, Szer J, Beresford J, et al., Factors affecting the
minimal residual disease quantification in adult patients compared with unrelated bone marrow transplant in adult outcome of allogeneic bone marrow transplantation for
with standard-risk acute lymphoblastic leukemia, Blood, patients with acute leukemia, Blood, 2009;113:1631–8. adult patients with refractory or relapsed acute leukaemia,
2006;107:1116–23. 46. Barker JN. Umbilical Cord Blood (UCB) Transplantation: An Br J Haematol, 1999:107:409–18.
28. Bassan R, Spinelli O, Oldani E, et al., Improved risk Alternative to the Use of Unrelated Volunteer Donors?, 65. Nordlander A, Mattsson J, Ringdén O, et al., Graft-versus-
classification for risk-specific therapy based on the Hematology Am Soc Hematol Educ Program, 2007;2007:55–61. host disease is associated with a lower relapse incidence
molecular study of minimal residual disease (MRD) in adult 47. Hamza NS, Lisgaris M, Yadavalli G, et al., Kinetics of myeloid after hematopoietic stem cell transplantation in patients
acute lymphoblastic leukemia (ALL), Blood, 2009; and lymphocyte recovery and infectious complications with acute lymphoblastic leukemia, Biol Blood Marrow
113:4153–62. after unrelated umbilical cord blood versus HLA-matched Transplant, 2004;10:195–20.
29. Pui CH, Schrappe M, Ribeiro RC, Niemeyer CM, Childhood unrelated donor allogeneic transplantation in adults, Br J 66. Stirewalt DL, Guthrie KA, Beppu L, et al., Predictors of
and adolescent lymphoid and myeloid leukemia, Hematology Haematol, 2004;124:488–98. relapse and overall survival in Philadelphia chromosome-
Am Soc Hematol Educ Program, 2004;118–45. 48. Parody R, Martino R, Rovira M, et al., Severe infections after positive acute lymphoblastic leukemia after transplantation,
30. Ferra C, Sanz J, Cámara R, et al., Predictive factors for unrelated donor allogeneic hematopoietic stem cell Biol Blood Marrow Transplant, 2003;9:206–12.
relapse in adult patients with high-risk acute lymphoblastic transplantation in adults: comparison of cord blood 67. Zecca M, Prete A, Rondelli R, et al., Chronic graft-versus-
leukemia submitted to na unrelated haematopoietic transplantation with peripheral blood and bone marrow host disease in children: incidence, risk factors, and
progenitor transplant, Bone Marrow Transplant, 2009;43(Suppl. transplantation, Biol Blood Marrow Transplant, 2006;12:734–48. important outcome, Blood, 2002;100:1192–1200.
1):139a. 49. Barker J, Hough RE, Van Burik JAH, et al., Serious infection 68. Gassas A, Sung L, Saunders EF, Doyle J, Graft-versus-
31. Sierra J, Storer B, Hansen JA, et al., Transplantation of after unrelated donor transplantation in 136 children: leukemia effect in hematopoietic stem cell transplantation
marrow cells from unrelated donors for treatment of high- impact of stem cell source, Biol Blood Marrow Transplant, for pediatric acute lymphoblastic leukemia: significantly
risk acute leukemia: the effect of leukemic burden, donor 2005;11:362–70. lower relapse rate in unrelated transplantations, Bone
HLA-matching, and marrow cell dose, Blood, 2008;11: 50. Barker J, Weisdorf DJ, DeFor TE, et al., Transplantation of Marrow Transplant, 2007;40:951–5.
EUROPEAN HAEMATOLOGY 49
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