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Possible Role of Pigment-epithelium-derived Factor in Corneal Angiogenesis
pigment epithelium-derived factor (PEDF) to the neuroprotective molecular region of pigment 1997;75(6):649–52.
retinoblastoma cells and cerebellar granule neurons. epithelium-derived factor and its binding sites on motor 47. Philipp W, Speicher L, Humpel C, Expression of vascular
Evidence for a PEDF receptor, J Biol Chem, neurons, J Neurosci, 2002;22(21):9378–86. endothelial growth factor and its receptors in inflamed
1999;274:31605–12. 26. Jablonski M, Tombran-Tink J, Mrazek DA, et al., Pigment and vascularized human corneas, Invest Ophthalmol Vis Sci,
6. Simonovic M, Gettins PGW, Volz K, Crystal structure of epithelium-derived factor supports normal development 2000;41:2514–22.
human PEDF, a potent antiangiogenic and neurite of photoreceptor neurons and opsin expression after 48. Cursifien C, Rummelt C, Kuchle M,
growth-promoting factor, Proc Natl Acad Sci U S A, retinal pigment epithelium removal, J Neurosci, 2000;20: Immunohistochemical localization of vascular
2001;98(20):11131–5. 7149–57. endothelial growth factor, transforming growth factor
7. Meyer C, Notari L, Becerra SP, Mapping the type I 27. Dawson DW, Volpert OV, Gillis P, et al., Pigment alpha, and transforming growth factor beta1 in human
collagen-binding site on pigment epithelium-derived epithelial-derived factor; a potent inhibitor of corneas with vascularization, Cornea, 2000;19:526–33.
factor. Implications for its antiangiogenic activity, J Biol angiogenesis, Science, 1999;285:245–8. 49. Ambati B, Nozaki M, Singh N, et al., Corneal vascularity
Chem, 2002;277(47):45400–454007. 28. Cao W, Tombran-Tink J, Elias R, et al., In vivo protection of is due to soluble VEGF receptor-1, Nature,
8. Yasui N, Mori T, Morito D, et al., Dual-site recognition of photoreceptors from light damage by pigment 2006;443:993–7.
different extracellular matrix components by epithelium-derived factor, Invest Ophthalmol Vis Sci, 50. Bahar I, Kaiserman I, McAllum P, et al., Subconjunctival
antiangiogenic/neurotrophic serpin, PEDF, Biochemistry, 2001;42:1646–52. bevacizumab injection for corneal neovascularization,
2003;42(11):3160–67. 29. Gao GQ, Li Y, Zhang DC, et al., Unbalanced expression of Cornea, 2008;27(2):142–7.
9. Alberdi EM, Glycosaminoglycans in human VEGF and PEDF in ischemia-induced retinal 51. Kim T, Kim SW, Kim S, et al., Inhibition of experimental
retinoblastoma cells: heparan sulfate, a modulator of neovascularization, FEBS Lett, 2001;489:270–76. corneal vascularisation by using subconjunctival injection
the pigment epithelium-derived factor-receptor 30. Stellmach VV, Crafoord SE, Zhou W, et al., Prevention of of bevacizumab (Avastin), Cornea, 2008;27(3):349–52.
interactions, BMC Biochemistry, 2003;4:1. ischemia-induced retinopathy by the natural ocular 52. Papathanassiou M, Thedossiadis P, Liarakos V, et al.,
10. Cai J, Jiang WG, Grant MB, et al., Pigment epithelium- antiangiogenic agent pigment epithelium-derived factor, Inhibition of corneal neovascularisation by
derived factor inhibits angiogenesis via regulated Proc Natl Acad Sci U S A, 2001;98:2593–7. subconjunctival bevacizumab in an animal model, Am J
intracellular proteolysis of vascular endothelial growth 31. Ogata N, Tombran-Tink J, Jo N, et al., Upregulation of Ophthalmol, 2008;145(3):424–31.
factor receptor 1, J Biol Chem, 2006;281(6):3604–13. pigment epithelium-derived factor after laser 53. Bahar I, Kaiserman I, McAllum P, et al., Subconjunctival
11. Notari, L, Baladron V, Aroca-Aguilar JD, et al., photocoagulation, Am J Ophthalmol, 2001;132:427–9. bevacizumab injection for corneal neovascularization in
Identification of a lipase-linked cell membrane receptor 32. Ohno-Matsui K, Morita I, Tombran-Tink J, et al., Novel recurrent pterygium, Current Eye Res, 2008;33:23–8.
for pigment epithelium-derived factor, J Biol Chem, mechanism for age-related macular degeneration: an 54. Chen WL, Lin CT, Chen MY, et al., Successful inhibition of
2006;281(49):38022–37. equilibrium shift between the angiogenesis factors VEGF corneal neovascularisation formation by subconjunctival
12. Zhang SX, Wang JJ, Gao G, et al., Pigment epithelium- and PEDF, J Cell Phys, 2001;189:323–33. injection of bevacizumab (Avastin) in various animal
derived growth factor downregulates vascular 33. Spranger J, Osterhoff M, Reinmann M, et al., Loss of models, ARVO abstract, 2008, program number/poster
endothelial growth factor (VEGF) expression and inhibits antiangiogenic pigment epithelium-derived factor in board number 1471/D1019.
VEGF-VEGF receptor 2 binding in diabetic retinopathy, J patients with angiogenic eye disease, Diabetes, 2001; 55. Rosner M, Habot-Wilner Z, Ivanir Y, et al., The inhibitory
Mol Endocrin, 2006;37(1):1–12. 50(12):2641–5. effect of different concentrations of topical bevacizumab
13. Valnickova Z, Petersen SV, Nielsen SB, et al., Heparin 34. Holekamp NM, Bouck N, Volpert O, Pigment epithelium- on corneal neovascularisation, ARVO abstract, 2008,
binding induces a conformational change in pigment derived factor is deficient in the vitreous of patients program number/poster board number 1473/D1021.
epithelium-derived factor, J Biol Chem, 2007;282(9):6661–7. with choroidal neovascularization due to age-related 56. Avisar I, Dratviman O, Kremer I, et al., Therapeutic effect of
14. Tombran-Tink J, Johnson L, Neuronal differentiation of macular degeneration, Am J Ophthalmol, 2002;134:220–27. subconjunctival and intraocular bevacizumab (Avastin)
retinoblastoma cells induced by medium conditioned by 35. Duh E, Yang HS, Suzuma I, et al., Pigment epithelium- injections in a mouse model of corneal
human RPE cells, Invest Ophthalmol Vis Sci, 1989;30:1700–7. derived factor suppresses ischemia-induced retinal neovascularisation, ARVO abstract, 2008, program
15. Karakousis P, John SK, Kathryn C, et al., Localization of vascularization and VEGF-induced migration and number/poster board number 3745.
pigment epithelium-derived factor (PEDF) in developing growth, Invest Ophthalmol Vis Sci, 2002;43(3):821–9. 57. Moriyama AS, Moraes Filho MN, Furlani B, et al., Effect of
and adult human ocular tissues, Mol Vis, 2001;7:154–63. 36. Ogata N, Wada M, Tsuyoshi O, et al., Expression of topical bevacizumab on corneal angiogenesis in the rabbit
16. Ortego J, Escribano J, Becerra SP, et al., Gene expression pigment epithelium-derived factor in normal adult rat model, ARVO abstract, 2008, program number/poster
of the neurotrophic PEDF in the human ciliary eye and experimental choroidal neovascularisation, board number 3744.
epithelium, Invest Ophthalmol Vis Sci, 1996;37:2759–67. Invest Ophthalmol Vis Sci, 2002;43(4):1168–75. 58. Abdiu O, Van Setten G, Antiangiogenic activity in tears:
17. Tombran-Tink J, Pawar H, Swaroop A, et al., Localization 37. Ogata N, Nishikawa M, Nishimura T, et al., Unbalanced presence of pigment-epithelium-derived factor. New
of the gene for pigment epithelium-derived factor vitreous levels of pigment epithelium-derived factor and insights and preliminary results, Ophthalmic Res, 2008;
(PEDF) to chromosom17p13.1 and expression in vascular endothelial growth factor in diabetic 40(1):16–18.
cultured human retinoblastoma cells, Genomics, retinopathy, Am J Ophthalmol, 2002;134:348–53. 59. Jin J, Guan M, Sima J, et al., Decreased pigment
1994;19:266–72. 38. Abdiu O, Van Setten G, Detection of PEDF in subretinal epithelium-derived factor and increased vascular
18. Goliath R, Shugart Y, Janssens P, et al., Fine localization fluid of retinal detachment: possible role in prevention endothelial growth factor levels in pterygia, Cornea,
of the gene for autosomal Retinitis pigmentosa on of subretinal neovascularization: preliminary results, 2003;22(5):473–7.
chromosome 17p, Am J Hum Genet, 1995;57:962–5. Ophthalmic Res, 2006;38(4):189–92. 60. Shao C, Sima J, Zhang S, et al., Suppression of corneal
19. Koenekoop R, Pina AL, Loyer M, et al., Four polymorphic 39. Bhutto IA, McLeod DS, Hasegawa T, et al., Pigment neovascularisation by PEDF release from human
variations in the PEDF gene identified in the screening epithelium-derived factor (PEDF) and vascular amniotic membranes, Invest Ophthalmol Vis Sci,
of patients with Leber congenital amaurosis, Mol Vis, endothelial growth factor (VEGF) in aged human choroid 2004;45:1758–62.
1999;5:10. and eyes with age-related macular degeneration, Exp Eye 61. Dushku N, John M, Schultz GS, et al., Pterygia
20. Bilak MM, Corse AM, Bilak SR, et al., Pigment Res, 2006;82(1):99–110. pathogenesis: corneal invasion by matrix
epithelium-derived factor (PEDF) protects motor 40. Carmeliet P, Angiogenesis in health and disease, Nat Med, metalloproteinase (MMP) expressing altered limbsl basal
neurons from chronic glutamate-mediated 2003;6:653–60. stem cells and activation of fibroblasts, ARVO abstract,
neurodegeneration, J Neuropathol Exp Neurol, 41. Cursifien C, Kuchle M, Naumann GO, et al., Angiogenesis Invest Ophthalmol Vis Sci, 2000;41(4):S451, abstract 2388.
1999;58:719–28. in corneal diseases; histopathologic evaluation of 254 62. Di Girolamo N, Wakefield D, Coroneo MT, Differential
21. Houenou LJ, D´Costa AP, Li L, et al., Pigment epithelium- human corneal buttons with neovascularisation, Cornea, expression of matrix metalloproteinases and their tissue
derived factor promotes the survival and differentiation 1998;17:611–13. inhibitors at the advancing pterygium head, Invest
of developing spinal motor neurons, J Comp Neurol, 42. Chang J-H, Gabison E, Kato T, et al., Corneal Ophthalmol Vis Sci, 2000;41(13):4142–9.
1999;412:506–14. neovascularisation, Curr Opin Ophthalmol, 2001;12(4):242–9. 63. Hollborn M, Stathopoulos C, Steffen A, et al., Positive
22. Taniwaki T, Hirashima N, Becerra SP, et al., Pigment 43. Gimbrone MA, Cotran RS, Leapman SB, et al., Tumor feedback regulation between MMP-9 and VEGF in
epithelium-derived factor protects cultured cerebellar growth and neovascularisation: an experimental model human RPE cells, Invest Ophthalmol Vis Sci, 2007;48(9):
granule cells against glutamate-induced neurotoxicity, using the rabbit cornea, J Natl Cancer Inst, 1974;52(2): 4360–67.
J Neurochem, 1997;68(1):26–32. 413–27. 64. Kvanta A, Sarman S, Fagerholm P, et al., Expression of
23. Araki T, Taniwaki T, Becerra SP et al., Pigment 44. Kenyon BM, Voegt EE, Chen CC, et al., A model of matrix metalloproteinase-2 (MMP-2) and vascular
epithelium-derived factor (PEDF) differentially protects angiogenesis in the mouse cornea, Invest Ophthalmol Vis Sci, endothelial growth factor (VEGF) in inflammation-
immature but not mature cerebellar granule cells 1996;37:1625–32. associated corneal neovascularization, Exp Eye Res,
against apoptotic cell death, J Neurosci Res, 1998;53:7–15. 45. Auerbach R, Lewis R, Shinners B, et al., Angiogenesis 2000;70:419–28.
23. Yabe T, Wilson D, Schwartz JP, NFkappaB activation is Assays; A critical overview, Clinical Chemistry, 2003;49:1: 65. Notari L, Miller A, Martinez A, et al., Pigment epithelium-
required for the neuroprotective effects of pigment 32–40. derived growth factor is a substrate for matrix
epithelium-derived factor (PEDF) on cerebellar granule 46. Van Setten G, Vascular endothelial growth factor (VEGF) metalloproteinase type 2 and type 9: implications for
neurons, J Biol Chem, 2001;276(46):43313–19. in normal human corneal epithelium; detection and downregulation in hypoxia, Invest Ophthalmol Vis Sci,
25. Bilak MM, Becerra SP, Vincent AM, et al., Identification of physiological importance, Acta Ophthalmol Scand, 2005;46(8):2736–47.
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