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Evaluating Central Serous Chorioretinopathy with Multifocal Electroretinogram
Figure 1: Affected Eye at Presentation – Case 2
Figure 2: Affected Eye After Recovery – Case 2
Patient/normal projection Patient/normal projection
A
Normal reference
A Normal reference
BC
A: The multifocal electroretinogram 3D plot of retinal responses is markedly pathological. BC
B: Fluorescein angiography in the early phase with evident leaking point. C: Fluorescein
angiography in the late phase.
A: The multifocal electroretinogram 3D plot of retinal responses is greatly improved.
B: Fluorescein angiography in the early phase shows the absence of the leaking
mf-ERG stimuli location and anatomical areas corresponded roughly
point. C: Fluorescein angiography in the late phase.
as follows: ring 1 to the fovea, ring 2 to the parafovea, ring 3 to the
Figure 3: Fellow Unaffected Eye – Case 2
perifovea, ring 4 to the near periphery and ring 5 to the central part of
the middle periphery. The amplitude of each group was scaled to
Patient/normal projection
reflect the angular size of the stimulus hexagon that produces the
response. These averages give a more accurate view of the relative
response densities of each group. The average retinal response
density of the retinal area corresponding to ring 1 (fovea) is
approximately 22.97nV/deg
2
, to ring 2 (parafovea) is 12.17nV/deg
2
, to
ring 3 (perifovea) is 11.8nV/deg
2
, to ring 4 (near periphery) is
10nV/deg
2
and to ring 5 is roughly 10nV/deg
2
. The retinal response
density decreases with eccentricity, although there is no further
decrease from ring 4 to ring 5.
Statistical Analysis
The paired t-test was used to study the significance of test–re-test
differences. If the pairing was not effective or the distribution did not
pertain to Gaussian parameters, the Mann-Whitney non-parametric
test was used. Furthermore, the Mann-Whitney test was used to A Normal reference
compare the mean differences of the tests with the sample of 33
normal individuals of similar age.
Results
At presentation in all patients, the best corrected VA of the affected
eyes ranged from 0.2 to 1.0 (standard Snellen chart) (see Table 1). The
mean VA was 0.595 (SD 0.216). After the resolution of CSCR, the best
corrected VA of the affected eyes ranged from 0.6 to 1.0. The mean
BC
VA was 0.767 (SD 0.139).
A: The multifocal electroretinogram 3D plot of retinal responses is normal. B, C: The
fluorescein angiography in the early and late phase is normal.
Multifocal Electroretinogram Results
The results of the MF-ERG are summarised in Table 1. At presentation, the foveal area, was 11.29nV/deg
2
(range 6.01–16.8nV/deg
2
, SD 3.14).
the average mean retinal response density in area 1, which represents The mean value is 50.8% compared lower with normal controls (mean
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