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Contents
Foreword
Martin Silink 8
President, International Diabetes Federation (IDF), and Professor, Paediatric Endocrinology,
University of Sydney and The Children’s Hospital at Westmead
Current Issues International Health and Diabetes
Diabetes and Tuberculosis – Old Associates Posing a Renewed Public Health Challenge 10
Anil Kapur,
1
Anthony D Harries,
2
Knut Lönnroth,
3
Ib C Bygbjerg
4
and Pierre Lefèbvre
5
1. Managing Director, World Diabetes Foundation; 2. Senior Advisor, International Union
Against Tuberculosis and Lung Diseases; 3. Medical Officer, Stop TB Department, World Health
Organization; 4. Professor, Department of International Health, Medical Microbiology and Immunology,
University of Copenhagen; 5. Emeritus Professor of Medicine, University of Liège
Diabetes in Sub-Saharan Africa – Overview of a Looming Health Challenge 13
Felix K Assah
1
and Jean-Claude Mbanya
2
1. Doctoral Student, MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge;
2. Professor of Medicine and Endocrinology, Department of Internal Medicine and Specialities,
Faculty of Medicine and Biomedical Sciences, University of Yaoundé I
International Diabetes Federation – The Global Voice for Diabetes 18
Ann Keeling
Chief Executive Officer and Executive Director, International Diabetes Federation (IDF)
Diabetes Pathophysiology and Genetics
Mitochondrial Dysfunction in Type 2 Diabetes – An Update 20
Muhammad A Abdul-Ghani
1
and Ralph A DeFronzo
2
1. Assistant Professor of Medicine; 2. Professor of Medicine, and Chief, Division of Diabetes,
University of Texas Health Science Center at San Antonio
Thymus Dysfunction in the Development of Type 1 Diabetes and
Endocrine Autoimmune Diseases 24
Vincent Geenen
1
and Olivier Dardenne
2
1. Director of Research; 2. Research Associate, Centre of Immunoendocrinology,
Institute of Pathology, University of Liège
Gene Variants for Obesity and Type 2 Diabetes – A Shared Aetiology? 27
Clara C Elbers,
1
Marcel GM Wolfs
2
and Timon W van Haeften
2,3
1. Complex Genetics Section, Department of Biomedical Genetics, Julius Centre for Health Sciences and
Primary Care, University Medical Centre Utrecht; 2. Department of Medical Biology, University of Groningen;
3. University Medical Centre Utrecht
Diabetes Management
Screening for Type 2 Diabetes – The ADDITION Netherlands Study 32
Guy EHM Rutten
1
and Paul GH Janssen
2
1. Professor of Diabetology; 2. General Practitioner, Julius Centre for Health Sciences and Primary Care,
University Medical Centre Utrecht
Incretin Mimetics
Liraglutide – A Once-daily Human Glucagon-like Peptide-1 Analogue
Treatment for Type 2 Diabetes 38
Chantal Mathieu
Professor of Medicine, Catholic University Leuven, and Head of Endocrinology, University Hospital Gasthuisberg
4 EUROPEAN ENDOCRINOLOGY