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Cardiac Imaging for Assessment of Left Ventricular Thrombus
contrast use have been associated with improved resource utilization, modalities. Improved thrombus detection has facilitated identification of
altered therapeutic management, and overall cost savings.
20
Contrast structural risk factors for thrombus formation: infarct size, contractile
can also be used for tissue characterization, which provides further dysfunction, and aneurysmal remodeling. n
benefit for thrombus detection versus anatomical imaging.
2,4,15,16
Jonathan W Weinsaft, MD, is an Assistant Professor of Medicine at Weill Medical
Both perfusion echo and DE-MRI have been used to detect thrombus
College of Cornell University, where he directs the cardiac magnetic resonance
based on avascular tissue characteristics; this approach has been imaging program.
shown to be superior to anatomical imaging for each of these
1. Mollet NR, Dymarkowski S, Volders W, et al., Visualization of 1988;60:104–10. Radiology, 2008;248:807–16.
ventricular thrombi with contrast-enhanced magnetic 15. Kirkpatrick JN, Wong T, Bednarz JE, et al., Differential 31. Cheitlin MD, Armstrong WF, Aurigemma GP, et al.,
resonance imaging in patients with ischemic heart disease, diagnosis of cardiac masses using contrast ACC/AHA/ASE 2003 Guideline Update for the Clinical
Circulation, 2002;106:2873–6. echocardiographic perfusion imaging, J Am Coll Cardiol, Application of Echocardiography: summary article. A report
2. Srichai MB, Junor C, Rodriguez LL, et al., Clinical, imaging, 2004;43:1412–19. of the American College of Cardiology/American Heart
and pathological characteristics of left ventricular thrombus: 16. Mansencal N, Revault-d’Allonnes L, Pelage JP, et al., Association Task Force on Practice Guidelines
a comparison of contrast-enhanced magnetic resonance Usefulness of contrast echocardiography for assessment of (ACC/AHA/ASE Committee to Update the 1997 Guidelines
imaging, transthoracic echocardiography, and intracardiac masses, Arch Cardiovasc Dis, 2009;102:177–83. for the Clinical Application of Echocardiography), J Am Soc
transesophageal echocardiography with surgical or 17. Krauser DG, Cham MD, Tortolani AJ, et al., Clinical utility of Echocardiogr, 2003;16:1091–1110.
pathological validation, Am Heart J, 2006;152:75–84. delayed-contrast computed tomography for tissue 32. Visser CA, Kan G, David GK, Lie KI, Durrer D, Two dimensional
3. Weinsaft JW, Kim HW, Shah DJ, et al., Detection of left characterization of cardiac thrombus, J Cardiovasc Comput echocardiography in the diagnosis of left ventricular
ventricular thrombus by delayed-enhancement Tomogr, 2007;1:114–18. thrombus. A prospective study of 67 patients with anatomic
cardiovascular magnetic resonance prevalence and markers 18. Mansencal N, Nasr IA, Pilliere R, et al., Usefulness of validation, Chest, 1983;83:228–32.
in patients with systolic dysfunction, J Am Coll Cardiol, contrast echocardiography for assessment of left ventricular 33. Ezekowitz MD, Wilson DA, Smith EO, et al., Comparison of
2008;52:148–57. thrombus after acute myocardial infarction, Am J Cardiol, Indium-111 platelet scintigraphy and two-dimensional
4. Weinsaft JW, Kim RJ, Ross M, et al., Contrast-enhanced 2007;99:1667–70. echocardiography in the diagnosis of left ventricular
anatomic imaging as compared to contrast-enhanced tissue 19. Thanigaraj S, Schechtman KB, Perez JE, Improved thrombi, N Engl J Med, 1982;306:1509–13.
characterization for detection of left ventricular thrombus, echocardiographic delineation of left ventricular thrombus 34. Lamas GA, Vaughan DE, Pfeffer MA, Left ventricular
J Am Coll Cardiol Img, 2009;2:969–79. with the use of intravenous second-generation contrast thrombus formation after first anterior wall acute
5. Asinger RW, Mikell FL, Elsperger J, Hodges M, Incidence of image enhancement, J Am Soc Echocardiogr, 1999;12:1022–6. myocardial infarction, Am J Cardiol, 1988;62:31–5.
left-ventricular thrombosis after acute transmural 20. Kurt M, Shaikh KA, Peterson L, et al., Impact of contrast 35. Greaves SC, Zhi G, Lee RT, et al., Incidence and natural
myocardial infarction. Serial evaluation by two-dimensional echocardiography on evaluation of ventricular function and history of left ventricular thrombus following anterior wall
echocardiography, N Engl J Med, 1981;305:297–302. clinical management in a large prospective cohort, J Am Coll acute myocardial infarction, Am J Cardiol, 1997;80:442–8.
6. Domenicucci S, Chiarella F, Bellotti P, et al., Long-term Cardiol, 2009;53:802–10. 36. Spirito P, Bellotti P, Chiarella F, et al., Prognostic significance
prospective assessment of left ventricular thrombus in 21. Mulvagh SL, Rakowski H, Vannan MA, et al., American and natural history of left ventricular thrombi in patients
anterior wall acute myocardial infarction and implications Society of Echocardiography Consensus Statement on the with acute anterior myocardial infarction: a two-dimensional
for a rational approach to embolic risk, Am J Cardiol, Clinical Applications of Ultrasonic Contrast Agents in echocardiographic study, Circulation, 1985;72:774–80.
1999;83:519–24. Echocardiography, J Am Soc Echocardiogr, 2008;21:1179–1201, 37. Toth C, Ujhelyi E, Fulop T, Istvan E, Clinical predictors of early
7. Motro M, Barbash GI, Hod H, et al., Incidence of left quiz 1281. left ventricular thrombus formation in acute myocardial
ventricular thrombi formation after thrombolytic therapy 22. Revised Healthcare Professional Letter (May 6, 2008) and infarction, Acta Cardiol, 2002;57:205–11.
with recombinant tissue plasminogen activator, heparin, and Full Prescribing Information for Definity. Available at: 38. Visser CA, Kan G, Meltzer RS, et al., Long-term follow-up of
aspirin in patients with acute myocardial infarction, Am Heart www.definityimaging.com/prescribing_info.html (accessed left ventricular thrombus after acute myocardial infarction. A
J, 1991;122:23–6. August 17, 2009). two-dimensional echocardiographic study in 96 patients,
8. Blondheim DS, Jacobs LE, Kotler MN, et al., Dilated 23. Kusnetzky LL, Khalid A, Khumri TM, et al., Acute mortality in Chest, 1984;86:532–6.
cardiomyopathy with mitral regurgitation: decreased survival hospitalized patients undergoing echocardiography with and 39. Pizzetti G, Belotti G, Margonato A, et al., Thrombolytic
despite a low frequency of left ventricular thrombus, Am without an ultrasound contrast agent: results in 18,671 therapy reduces the incidence of left ventricular thrombus
Heart J, 1991;122:763–71. consecutive studies, J Am Coll Cardiol, 2008;51:1704–6. after anterior myocardial infarction. Relationship to vessel
9. Neskovic AN, Marinkovic J, Bojic M, Popovic AD, Predictors 24. Dolan MS, Gala SS, Dodla S, et al., Safety and efficacy of patency and infarct size, Eur Heart J, 1996;17:421–8.
of left ventricular thrombus formation and disappearance commercially available ultrasound contrast agents for rest 40. Grothues F, Smith GC, Moon JC, et al., Comparison of
after anterior wall myocardial infarction, Eur Heart J, and stress echocardiography a multicenter experience, J Am interstudy reproducibility of cardiovascular magnetic
1998;19:908–16. Coll Cardiol, 2009;53:32–8. resonance with two-dimensional echocardiography in
10. Porter A, Kandalker H, Iakobishvili Z, et al., Left ventricular 25. Herzog CA, Incidence of adverse events associated with use normal subjects and in patients with heart failure or left
mural thrombus after anterior ST-segment-elevation acute of perflutren contrast agents for echocardiography, JAMA, ventricular hypertrophy, Am J Cardiol, 2002;90:29–34.
myocardial infarction in the era of aggressive reperfusion 2008;299:2023–5. 41. Thiele H, Nagel E, Paetsch I, et al., Functional cardiac MR
therapy—still a frequent complication, Coron Artery Dis, 26. Wei K, Mulvagh SL, Carson L, et al., The safety of Definity imaging with steady-state free precession (SSFP)
2005;16:275–9. and Optison for ultrasound image enhancement: a significantly improves endocardial border delineation
11. Chiarella F, Santoro E, Domenicucci S, et al., Predischarge retrospective analysis of 78,383 administered contrast without contrast agents, J Magn Reson Imaging, 2001;14:362–7.
two-dimensional echocardiographic evaluation of left doses, J Am Soc Echocardiogr, 2008;21:1202–6. 42. Kim RJ, Fieno DS, Parrish TB, et al.,  Relationship of MRI
ventricular thrombosis after acute myocardial infarction in 27. Nucifora G, Marsan NA, Siebelink HM, et al., Safety of delayed contrast enhancement to irreversible injury, infarct
the GISSI-3 study, Am J Cardiol, 1998;81:822–7. contrast-enhanced echocardiography within 24 h after age, and contractile function, Circulation, 1999;100:
12. Nihoyannopoulos P, Smith GC, Maseri A, Foale RA, The acute myocardial infarction, Eur J Echocardiogr, 2008;9:816–18. 1992–2002.
natural history of left ventricular thrombus in myocardial 28. Aggeli C, Giannopoulos G, Roussakis G, et al., Safety of 43. Fieno DS, Kim RJ, Chen EL, et al., Contrast-enhanced
infarction: a rationale in support of masterly inactivity, J Am myocardial flash-contrast echocardiography in combination magnetic resonance imaging of myocardium at risk:
Coll Cardiol, 1989;14:903–11. with dobutamine stress testing for the detection of distinction between reversible and irreversible injury
13. Stratton JR, Lighty GW Jr, Pearlman AS, Ritchie JL, Detection ischaemia in 5250 studies, Heart, 2008;94:1571–7. throughout infarct healing, J Am Coll Cardiol, 2000;36:1985–91.
of left ventricular thrombus by two-dimensional 29. Katayama H, Yamaguchi K, Kozuka T, et al., Adverse 44. Jugdutt BI, Tang SB, Khan MI, Basualdo CA, Functional
echocardiography: sensitivity, specificity, and causes of reactions to ionic and nonionic contrast media. A report impact of remodeling during healing after non-Q wave
uncertainty, Circulation, 1982;66:156–66. from the Japanese Committee on the Safety of Contrast versus Q wave anterior myocardial infarction in the dog,
14. Johannessen KA, Nordrehaug JE, von der Lippe G, Vollset SE, Media, Radiology, 1990;175:621–8. J Am Coll Cardiol, 1992;20:722–31.
Risk factors for embolisation in patients with left ventricular 30. Prince MR, Zhang H, Morris M, et al., Incidence of
thrombi and acute myocardial infarction, Br Heart J, nephrogenic systemic fibrosis at two large medical centers,
US CARDIOLOGY 33
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