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Imaging
accuracy for detecting CAD. The advantages of SPECT include a higher
feasibility, higher sensitivity (especially for single-vessel disease
Nuno Cortez-Dias, MD, is a Cardiology Fellow at Santa
involving the left circumflex), and higher accuracy in the presence of
Maria University Hospital in Lisbon and a graduate
teaching assistant on the ‘Introduction to Clinical
extensive resting wall motion abnormalities. The advantages of SEcho
Medicine’ course at Lisbon University Medical School.
include higher specificity, wider availability, lower cost, and, most
Between 2003 and 2006 he served as a teaching assistant
importantly, its radiation-free nature.
5
Recently, the recommendations
in histology and embryology at the same institution. He is
also a student on the doctoral program for physicians at
of the European Association of Echocardiography defended that SEcho
the Calouste Gulbenkian Foundation. Dr Cortez-Dias’s
compares favorably with SPECT, considering the integrated
main fields of interest are echocardiographic
risk–benefit balance.
5
All SEcho methods (treadmill exercise, bicycle
quantification of myocardial function in ischemic heart disease, myocardial
dyssynchrony, and resynchronization therapy. He is the author or co-author of 12 papers
exercise, high-dose dobutamine, and high-dose dipyridamole)
published in peer-reviewed international journals and over 100 presentations at major
have similar diagnostic and prognostic accuracy. The choice of one
scientific events. He graduated from Lisbon University Medical School in 2003.
over the other is strictly due to relative contraindications and the
ability of patients to exercise.
5,26
Among the available stressors
Fausto J Pinto, MD, PhD, FESC, FACC, FASE, FSCAI, is a
Professor of Cardiology at Lisbon University Medical
exercise is the most used, dobutamine the best test for viability, and
School and a Senior Consultant at the University Hospital
dipyridamole the safest pharmacological stressor that is the most of Santa Maria. He also serves as Director of the Lisbon
suitable for combined wall motion CFR assessment.
5 Cardiovascular Institute. Professor Pinto serves or has
served as President of the Association for Research and
Development of the Faculty of Medicine (2004–2010),
Conclusion Chairman of the Congress Programme Committee of the
In conclusion, SEcho has a very high diagnostic accuracy for detecting
European Society of Cardiology (2008–2010), President and
Founder of the European Association of Echocardiography (2002–2004), and Councillor
ischemia and viability. Its wide acceptance in clinical practice reflects its
of the European Society of Cardiology (2004– 2006). In addition, he serves on the Editorial
safety and prognostic value, which has also been proved in several large- Board of several international journals and is Editor in Chief of the Portuguese Journal of
scale multicenter trials. The recent introduction of other methods, such
Cardiology. Professor Pinto graduated from Lisbon University Medical School in 1984 and
completed his cardiology fellowship at Santa Maria University Hospital in Lisbon and
as myocardial deformation assessment and contrast echocardiography,
Stanford University Medical School, where he stayed for four years as a post-doctoral
have further expanded the use of SEcho as one of the main tools in the fellow and then as clinical attending in the echocardiography laboratory.
management of patients with ischemic heart disease. n
1. Reant P, Labrousse L, Lafitte S, et al., Experimental validation myocardial fractional flow reserve, Eur Heart J, 2007;28: Echocardiogr, 2007;8:438–48.
of circumferential, longitudinal, and radial 2-dimensional 1425–32. 19. Fox K, Garcia MA, Ardissino D, et al., Guidelines on the
strain during dobutamine stress echocardiography in 11. Hanekom L, Cho GY, Leano R, et al., Comparison of two- management of stable angina pectoris: executive summary:
ischemic conditions, J Am Coll Cardiol, 2008;51:149–57. dimensional speckle and tissue Doppler strain The Task Force on the Management of Stable Angina
2. Ling LH, Pellikka PA, Mahoney DW, et al., Atropine measurement during dobutamine stress echocardiography: Pectoris of the European Society of Cardiology, Eur Heart J,
augmentation in dobutamine stress echocardiography: role an angiographic correlation, Eur Heart J, 2007;28:1765–72. 2006;27:1341–81.
and incremental value in a clinical practice setting, J Am Coll 12. Bjork Inqul C, Rozis E, Slordahl SA, et al., Incremental value 20. Cheitlin MD, Armstrong WF, Aurigemma GP, et al.,
Cardiol, 1996;28:551–7. of strain rate imaging to wall motion analysis for prediction ACC/AHA/ASE 2003 guideline update for the clinical
3. Secknus MA, Marwick TH, Evolution of dobutamine of outcome in patients undergoing dobutamine stress application of echocardiography—summary article: a report
echocardiography protocols and indications: safety and side echocardiography, Circulation, 2007;115:1252–9. of the American College of Cardiology/American Heart
effects in 3,011 studies over 5 years, J Am Coll Cardiol, 13. Walimbe V, Garcia M, Lalude O, et al., Quantitative real-time Association Task Force on Practice Guidelines
1997;29:1234–40. 3-dimensional stress echocardiography: a preliminary (ACC/AHA/ASE Committee to Update the 1997 Guidelines
4. Picano E, Molinaro S, Pasanisi E, The diagnostic accuracy of investigation of feasibility and effectiveness, J Am Soc for the Clinical Application of Echocardiography), J Am Coll
pharmacological stress echocardiography for the Echocardiogr, 2007;20:13–22. Cardiol, 2003;42:954–70.
assessment of coronary artery disease: a meta-analysis, 14. Ahmad M, Xie T, McCulloch M, et al., Real-time three- 21. Rizzello V, Poldermans D, Bax JJ, Assessment of myocardial
Cardiovasc Ultrasound, 2008;6:30. dimensional dobutamine stress echocardiography in viability in chronic ischemic heart disease: current status,
5. Sicari R, Nihoyannopoulos P, Evangelista A, et al., Stress assessment stress echocardiography in assessment of Q J Nucl Med Mol Imaging, 2005;49:81–96.
echocardiography expert consensus statement: European ischemia: comparison with two-dimensional dobutamine 22. Aggeli C, Giannopoulos G, Roussakis G, et al., Pre-ejection
Association of Echocardiography (EAE) (a registered branch stress echocardiography, J Am Coll Cardiol, 2001;37:1303–9. tissue-Doppler velocity changes during low dose
of the ESC), Eur J Echocardiogr, 2008;9:415–37. 15. Lowenstein J, Tiano C, Marquez G, et al., Simultaneous dobutamine stress predict segmental myocardial viability,
6. Rizzello V, Schinkel AF, Bax JJ, et al., Individual prediction of analysis of wall motion and coronary flow reserve of Hellenic J Cardiol, 2007;48:23–29.
functional recovery after coronary revascularization in the left anterior descending coronary artery by 23. Hanekom L, Jenkins C, Jeffries L, et al., Incremental value of
patients with ischemic cardiomyopathy: the scar-to-biphasic transthoracic doppler echocardiography during strain rate analysis as an adjunct to wall-motion scoring for
model, Am J Cardiol, 2003;91:1406–9. dipyridamole stress echocardiography, J Am Soc assessment of myocardial viability by dobutamine
7. Hoffmann R, Lethen H, Marwick T, et al., Analysis of Echocardiogr, 2003;16:607–13. echocardiography: a follow-up study after revascularization,
interinstitutional observer agreement in interpretation of 16. Rigo F, Sicari R, Gherardi S, et al., The additive prognostic Circulation, 2005;112:3892–900.
dobutamine stress echocardiograms, J Am Coll Cardiol, value of wall motion abnormalities and coronary flow 24. Cianfrocca C, Pelliccia F, Pasceri V, et al., Strain rate analysis
1996;27:330–36. reserve during dipyridamole stress echo, Eur Heart J, and levosimendan improve detection of myocardial viability
8. Yamada E, Garcia M, Thomas JD, et al., Myocardial Doppler 2008;29:79–88. by dobutamine echocardiography in patients with post-
velocity imaging—a quantitative technique for interpretation 17. Elhendy A, O’Leary EL, Xie F, et al., Comparative accuracy of infarction left ventricular dysfunction: a pilot study, J Am Soc
of dobutamine echocardiography, Am J Cardiol, 1998;82: real-time myocardial contrast perfusion imaging and wall Echocardiogr, 2008;21:1068–74.
806–10. motion analysis during dobutamine stress echocardiography 25. Becker M, Lenzen A, Ocklenburg C, et al., Myocardial
9. Voigt JU, Nixdorff U, Bogdan R, et al., Comparison of for the diagnosis of coronary artery disease, J Am Coll Cardiol, deformation imaging based on ultrasonic pixel tracking to
deformation imaging and velocity imaging for detecting 2004;44:2185–91. identify reversible myocardial dysfunction, J Am Coll Cardiol,
regional inducible ischaemia during dobutamine stress 18. Hoffmann R, Borges AC, Kasprzak JD, et al., Analysis of 2008;51:1473–81.
echocardiography, Eur Heart J, 2004;25:1517–25. myocardial perfusion or myocardial function for detection of 26. Pellikka PA, Nagueh SF, Elhendy AA, et al., American Society
10. Weidemann F, Jung P, Hoyer C, et al., Assessment of the regional myocardial abnormalities. An echocardiographic of Echocardiography recommendations for performance,
contractile reserve in patients with intermediate coronary multicenter comparison study using myocardial contrast interpretation, and application of stress echocardiography,
lesions: a strain rate imaging study validated by invasive echocardiography and 2D echocardiography, Eur J J Am Soc Echocardiogr, 2007;20:1021–41.
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