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Posterior Segment Retina
growth-factor-free media.
89
Currently, clinical trials are ongoing to
determine a possible therapeutic effect of intranasal and intravenous Raul G Corredor is a graduate student in the
formulations of some of these peptides in Alzheimer’s disease and
Neurosciences Program at the Bascom Palmer Eye
Institute, University of Miami Miller School of Medicine.
other neurodegenerative diseases.
90
He trained as a neurologist, and his main interests are
neuroprotection and regeneration in the central
Conclusion
nervous system.
In summary, it is clear that many positive and negative signals balance
against each other to determine whether RGCs will survive or die
after an insult to the retina or optic nerve. Combinatorial approaches
Jeffrey L Goldberg is an Assistant Professor of
are more likely to maximise RGC neuroprotection, and many such Ophthalmology at the Bascom Palmer Eye Institute,
approaches have demonstrated efficacy in animal models. As we
University of Miami Miller School of Medicine. His
research interests include neuroprotection and
continue to decode the molecular mechanisms of apoptosis in RGCs,
regeneration and the use of stem cells and
other important potential pro-survival therapies may be incorporated nanotechnologies for ocular repair.
into a multifaceted approach. It will be important moving forward to
transition as many of these as possible into well-structured clinical
trials in humans. n
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