Azuara_Layout 1 21/01/2010 11:14 Page 18
Imaging and Navigation
Table 1: Studies of Confocal Scanning Laser Ophthalmoscopy
Author Imaging Study Population Reference QUADAS Comments
Device Standard Item Y/N
Pablo, 2009
30
HRT III Early glaucoma vs normal Stereoscopic 12/1 Ability of HRT to discriminate
photography early glaucoma similar to
assessment of stereophotographs
Saito, 2009
32
HRT II Early glaucoma vs normal VF 10/3 Performance of GPS and
MRA similar
Chauhan, 2009
54
HRT III Longitudinal study of Monoscopic 12/1 HRT performs at least as well as
software progressive glaucoma vs disc photographs disc photographs to detect
stable glaucoma glaucoma progression (cave:
monoscopic disc photographs)
Oddone, 2009
51
HRT III Different stages of VF 10/3 HRT parameters not good at early
glaucoma vs normal stages; sectorial analysis better than
global analysis
Vizzeri, 2009
55
HRT III Longitudinal study of Stereoscopic 12/0 Agreement between progression
progressive glaucoma vs photography 1 unclear identified by HRT and stereophotograph
stable glaucoma assessment was poor
Ferreras, 2007
33
HRT III Healthy vs glaucoma Stereoscopic 11/2 GPS and MRA have similar diagnostic
MRA vs GPS disc photography accuracy; both are influenced by
optic disc size and severity of disease
Bowd, 2009
56
HRT II Patients enrolled in the Progression in VF 9/1 TCA parameters can discriminate
Diagnostic innovations in and/or stereoscopic 3 unclear between progressing and stable
Glaucoma Study disc photographs eyes; low specificity in apparently
non-progressing patients (?)
Ferreras, 2008
57
HRT III Healthy vs glaucoma Stereoscopic 12/1 Compared with HRT-provided
photography and VF parameters, the linear discrimination
function (LDF) has higher
diagnostic ability
Ohkubo, 2007
31
HRT II Healthy vs glaucoma; Stereoscopic 8/4 HRT II outperforms non-mydriatic
screening disc photography 1 unclear stereoscopic disc photograhy
because of bad image quality in
glaucomatous eyes
De Leon-Ortega, 2007
35
HRT II Healthy vs glaucoma; Stereoscopic 9/3 MRA of HRT III showed highest
vs HRT III African vs European ancestry disc photography 1 unclear diagnostic ability; GPS showed
similar sensitivity but a considerably
lower specificity than MRA
Moreno-Montanes, 2008
34
HRT III Healthy vs OHT and glaucoma VF 7/2 Retrospective analysis of consecutive
4 unclear cases; GPS more sensitive but less
specific than MRA; MRA and GPS
agreement was low
GPS = glaucoma probability score; HRT = Heidelberg retina tomograph; MRA = Moorfields Regression Anaylsis; OHT = ocular hypertension; QUADAS = Quality Assessment of Diagnostic
Accuracy Studies; TCA = topographic change analysis; VF = visual field.
much faster scanning and better axial resolution than TD-OCT. Meditec, Inc. Dublin) has been studied. A good correlation between
3D OCT is also available and may be used to image the ONH. There the two instruments was found; however, when absolute values
are several SD-OCT devices commercially available, and it is likely were compared, a significant difference in RNFL thickness was
that further developments will appear in the future. detected. Therefore, measurements are not interchangeable and
cannot be compared directly. It was shown that RNFL
It is unclear whether the new SD-OCT technology will improve the measurements obtained by the Stratus OCT are generally higher
diagnostic performance with glaucoma. It seems that this may be than with the Cirrus OCT, except when the RNFL is very thin.
23–25
the case as a more accurate measurement technique for
assessment of the thickness of the retinal layers is provided. The Literature Review
capability of the new SD-OCT to detect localised RNFL defects, We have reviewed the most recent studies on diagnostic accuracy
documented on stereophotographs, was investigated. All currently of the above imaging technologies, and assessed the quality of
available SD-OCT instruments were able to confirm the structural the studies. For this purpose we conducted a comprehensive
glaucomatous damage.
21
It has been shown that RNFL thickness search of peer-reviewed literature in PubMed for the period
measurements obtained by SD-OCT correlated more strongly with January 2007 to June 2009. The search was limited to studies
localised visual field defects than scanning laser polarimetry.
22
published in English-language journals. The following search terms
were used: optical coherence tomography, scanning laser
The relationship between RNFL thickness measured by time- polarimetry, confocal scanning laser ophthalmoscopy and
domain (Stratus) and spectral-domain OCT (Cirrus HD; Carl Zeiss glaucoma. The search resulted in 326 citations. The abstracts of
18 EUROPEAN OPHTHALMIC REVIEW
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104 |
Page 105 |
Page 106 |
Page 107 |
Page 108 |
Page 109 |
Page 110 |
Page 111 |
Page 112 |
Page 113 |
Page 114 |
Page 115 |
Page 116