Erbs_European Cardiology 02/02/2010 10:25 Page 39
Cardiovascular Risk Reduction in Childhood – Evidence and Strategies
2008;32:749–56. Relat Metab Disord, 2004;28:833–41. 59. Chanoine JP, Hampl S, Jensen C, et al., Effect of orlistat on
19. Davis PH, Dawson JD, Riley WA, et al., Carotid intimal- 38. Butte NF, Comuzzie AG, Cole SA, et al., Quantitative weight and body composition in obese adolescents: a
medial thickness is related to cardiovascular risk factors genetic analysis of the metabolic syndrome in Hispanic randomized controlled trial, JAMA, 2005;293:2873–83.
measured from childhood through middle age: The children, Pediatr Res, 2005;58:1243–8. 60. Berkowitz RI, Fujioka K, Daniels SR, et al., Effects of
Muscatine Study, Circulation, 2001;104:2815–19. 39. Calle EE, Thun MJ, Petrelli JM, et al., Body-mass index and sibutramine treatment in obese adolescents: a
20. Järvisalo MJ, Jartti L, Nanto-Salonen K, et al., Increased mortality in a prospective cohort of U.S. adults, N Engl J randomized trial, Ann Intern Med, 2006;145:81–90.
aortic intima-media thickness: a marker of preclinical Med, 1999;341:1097–1105. 61. Burgert TS, Duran EJ, Goldberg-Gell R, et al., Short-term
atherosclerosis in high-risk children, Circulation, 2001;104: 40. Kiess W, Galler A, Reich A, et al., Clinical aspects of obesity metabolic and cardiovascular effects of metformin in
2943–7. in childhood and adolescence, Obes Rev, 2001;2:29–36. markedly obese adolescents with normal glucose
21. Agabiti-Rosei E, Porteri E, Rizzoni D, Arterial stiffness, 41. Cole TJ, Bellizzi MC, Flegal KM, et al., Establishing a tolerance, Pediatr Diabetes, 2008;9:567–76.
hypertension, and rational use of nebivolol, Vasc Health Risk standard definition for child overweight and obesity 62. de Jongh S, Lilien MR, op’t Roodt J, et al., Early statin
Manag, 2009;5:353–60. worldwide: international survey, BMJ, 2000;320:1240–43. therapy restores endothelial function in children with
22. Khoshdel AR, Carney SL, Arterial stiffness in kidney 42. Lobstein T, Frelut ML, Prevalence of overweight among familial hypercholesterolemia, J Am Coll Cardiol, 2002;40:
transplant recipients: an overview of methodology and children in Europe, Obes Rev, 2003;4:195–200. 2117–21.
applications, Urol J, 2008;5:3–14. 43. Jackson-Leach R, Lobstein T, Estimated burden of 63. Wiegman A, Hutten BA, de Groot E, et al., Efficacy and
23. Franklin SS, Khan SA, Wong ND, et al., Is pulse pressure paediatric obesity and co-morbidities in Europe. Part 1. safety of statin therapy in children with familial
useful in predicting risk for coronary heart disease? The The increase in the prevalence of child obesity in Europe hypercholesterolemia: a randomized controlled trial, JAMA,
Framingham heart study, Circulation, 1999;100:354–60. is itself increasing, Int J Pediatr Obes, 2006;1:26–32. 2004;292:331–7.
24. Blacher J, Asmar R, Djane S, et al., Aortic pulse wave 44. Lobstein T, Jackson-Leach R, Child overweight and obesity 64. Li JS, Baker-Smith CM, Smith PB, et al., Racial differences
velocity as a marker of cardiovascular risk in hypertensive in the USA: prevalence rates according to IOTF definitions, in blood pressure response to angiotensin-converting
patients, Hypertension, 1999;33:1111–17. Int J Pediatr Obes, 2007;2:62–4. enzyme inhibitors in children: a meta-analysis, Clin
25. Juonala M, Järvisalo MJ, Mäki-Torkko N, et al., Risk factors 45. Keller E, Gausche R, Meigen C, et al., Auxological Pharmacol Ther, 2008;84:315–19.
identified in childhood and decreased carotid artery computer based network for early detection of disorders 65. Lawson ML, Kirk S, Mitchell T, et al., One-year outcomes of
elasticity in adulthood: the Cardiovascular Risk in Young of growth and weight attainment, J Pediatr Endocrinol Metab, Roux-en-Y gastric bypass for morbidly obese adolescents:
Finns Study, Circulation, 2005;112:1486–93. 2002;15:149–56. a multicenter study from the Pediatric Bariatric Study
26. Li S, Chen W, Srinivasan SR, et al., Childhood blood 46. Briefel RR, Johnson CL, Secular trends in dietary intake in Group, J Pediatr Surg, 2006;41:137–43.
pressure as a predictor of arterial stiffness in young adults: the United States, Annu Rev Nutr, 2004;24:401–31. 66. August GP, Caprio S, Fennoy I, et al., Prevention and
the bogalusa heart study, Hypertension, 2004;43:541–6. 47. Kleiser C, Schaffrath RA, Mensink GB, et al., Potential treatment of pediatric obesity: an endocrine society
27. Sakuragi S, Abhayaratna K, Gravenmaker KJ, et al., determinants of obesity among children and adolescents clinical practice guideline based on expert opinion, J Clin
Influence of adiposity and physical activity on arterial in Germany: results from the cross-sectional KiGGS Study, Endocrinol Metab, 2008;93:4576–99.
stiffness in healthy children: the lifestyle of our kids study, BMC Public Health, 2009;9:46. 67. Caniano DA, Ethical issues in pediatric bariatric surgery,
Hypertension, 2009;53:611–16. 48. Kimm SY, Glynn NW, Kriska AM, et al., Longitudinal Semin Pediatr Surg, 2009;18:186–92.
28. Kallio K, Jokinen E, Hämäläinen M, et al., Decreased aortic changes in physical activity in a biracial cohort during 68. Steinbeck KS, The importance of physical activity in the
elasticity in healthy 11-year-old children exposed to adolescence, Med Sci Sports Exerc, 2000;32:1445–54. prevention of overweight and obesity in childhood: a
tobacco smoke, Pediatrics, 2009;123:e267–e273. 49. Ortega FB, Ruiz JR, Sjöström M, Physical activity, review and an opinion, Obes Rev, 2001;2:117–30.
29. Baker JL, Olsen LW, Sørensen TI, Childhood body-mass overweight and central adiposity in Swedish children and 69. Summerbell CD, Waters E, Edmunds LD, et al.,
index and the risk of coronary heart disease in adulthood, adolescents: the European Youth Heart Study, Int J Behav Interventions for preventing obesity in children, Cochrane
N Engl J Med, 2007;357:2329–37. Nutr Phys Act, 2007;4:61. Database Syst Rev, 2005;3:CD001871.
30. Smoak CG, Burke GL, Webber LS, et al., Relation of obesity 50. Dencker M, Thorsson O, Karlsson MK, et al., Daily physical 70. Doak CM, Visscher TL, Renders CM, et al., The prevention
to clustering of cardiovascular disease risk factors in activity related to aerobic fitness and body fat in an urban of overweight and obesity in children and adolescents: a
children and young adults. The Bogalusa Heart Study, Am J sample of children, Scand J Med Sci Sports, 2008;18:728–35. review of interventions and programmes, Obes Rev,
Epidemiol, 1987;125:364–72. 51. Körner A, Kratzsch J, Gausche R, et al., New predictors of 2006;7:111–36.
31. Reich A, Müller G, Gelbrich G, et al., Obesity and blood the metabolic syndrome in children—role of 71. van Sluijs EM, McMinn AM, Griffin SJ, Effectiveness of
pressure-results from the examination of 2365 adipocytokines, Pediatr Res, 2007;61:640–45. interventions to promote physical activity in children and
schoolchildren in Germany, Int J Obes Relat Metab Disord, 52 Reinehr T, Roth C, Menke T, et al., Adiponectin before and adolescents: systematic review of controlled trials, BMJ,
2003;27:1459–64. after weight loss in obese children, J Clin Endocrinol Metab, 2007;335:703.
32. Reinehr T, Andler W, Denzer C, et al., Cardiovascular risk 2004;89:3790–94. 72. Harris KC, Kuramoto LK, Schulzer M, et al., Effect of
factors in overweight German children and adolescents: 53. Meyer AA, Kundt G, Lenschow U, et al., Improvement of school-based physical activity interventions on body mass
relation to gender, age and degree of overweight, Nutr early vascular changes and cardiovascular risk factors in index in children: a meta-analysis, CMAJ, 2009;180:719–26.
Metab Cardiovasc Dis, 2005;15:181–7. obese children after a six-month exercise program, J Am 73. Walther C, Gaede L, Adams V, et al., Effect of increased
33. Reaven GM, Banting lecture 1988. Role of insulin Coll Cardiol, 2006;48:1865–70. exercise in school children on physical fitness and
resistance in human disease, Diabetes, 1988;37:1595–1607. 54. de Sousa G, Hussein A, Trowitzsch E, et al., Hemodynamic endothelial progenitor cells: a prospective randomized
34. Kahn R, Buse J, Ferrannini E, et al., The metabolic responses to exercise in obese children and adolescents trial, Circulation, 2009;120(22):2251–9.
syndrome: time for a critical appraisal. Joint statement before and after overweight reduction, Klin Padiatr, 74. Hakanen M, Lagström H, Kaitosaari T, et al., Development
from the American Diabetes Association and the 2009;221:237–40. of overweight in an atherosclerosis prevention trial
European Association for the Study of Diabetes, 55. Reinehr T, Andler W, Changes in the atherogenic risk factor starting in early childhood. The STRIP study, Int J Obes (Lond),
Diabetologia, 2005;48:1684–99. profile according to degree of weight loss, Arch Dis Child, 2006;30:618–26.
35. Weiss R, Dziura J, Burgert TS, et al., Obesity and the 2004;89:419–22. 75. Raitakari OT, Rönnemaa T, Järvisalo MJ, et al., Endothelial
metabolic syndrome in children and adolescents, N Engl J 56. Coppen AM, Risser JA, Vash PD, Metabolic syndrome function in healthy 11-year-old children after dietary
Med, 2004;350:2362–74. resolution in children and adolescents after 10 weeks of intervention with onset in infancy: the Special Turku
36. de Ferranti SD, Gauvreau K, Ludwig DS, et al., Prevalence weight loss, J Cardiometab Syndr, 2008;3:205–10. Coronary Risk Factor Intervention Project for children
of the metabolic syndrome in American adolescents: 57. Wunsch R, de Sousa G, Toschke AM, et al., Intima-media (STRIP), Circulation, 2005;112:3786–94.
findings from the Third National Health and Nutrition thickness in obese children before and after weight loss, 76. Kaitosaari T, Rännemaa T, Viikari J, et al., Low-saturated fat
Examination Survey, Circulation, 2004;110:2494–7. Pediatrics, 2006;118:2334–40. dietary counseling starting in infancy improves insulin
37. Lambert M, Paradis G, O’Loughlin J, et al., Insulin 58. Woo KS, Chook P, Yu CW, et al., Effects of diet and exercise sensitivity in 9-year-old healthy children: the Special Turku
resistance syndrome in a representative sample of on obesity-related vascular dysfunction in children, Coronary Risk Factor Intervention Project for Children
children and adolescents from Quebec, Canada, Int J Obes Circulation, 2004;109:1981–6. (STRIP) study, Diabetes Care, 2006;29:781–5.
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