Moncada_A4_template_04 16/03/2010 10:45 Page 72
Premature Ejaculation
1. McMahon CG, Althof S, Waldinger MD, et al., An evidence- 19. Ahlenius S, Larsson K, Specific involvement of central Psychopharmacol, 1997;17:208.
based definition of lifelong premature ejaculation: report of 5-HT1A receptors in the mediation of male rat ejaculatory 37. El Mansari M, Blier P, Responsiveness of 5-HT(1A) and
the International Society for Sexual Medicine Ad Hoc behavior, Neurochem Res, 1997;22:1065. 5-HT2 receptors in the rat orbitofrontal cortex after long-
Committee for the Definition of Premature Ejaculation, 20. Waldinger MD, Rietschel M, Nothen MM, et al., Familial term serotonin reuptake inhibition, J Psychiatry Neurosci,
BJU Int, 2008;102:338. occurrence of primary premature ejaculation, Psychiatr 2005;30:268.
2. Giuliano F, Hellstrom WJ, The pharmacological treatment of Genet, 1998;8:37. 38. Sharlip I, Diagnosis and treatment of premature ejaculation:
premature ejaculation, BJU Int, 2008;102:668. 21. Waldinger MD, Olivier B, Utility of selective serotonin the physician’s perspective, J Sex Med, 2005;2(Suppl. 2):103.
3. Waldinger MD, The neurobiological approach to premature reuptake inhibitors in premature ejaculation, Curr Opin 39. Patel K, Hellstrom WJ, Central regulation of ejaculation and
ejaculation, J Urol, 2002;168:2359. Investig Drugs, 2004;5:743. the therapeutic role of serotonergic agents in premature
4. Coolen LM, Allard J, Truitt WA, et al., Central regulation of 22. Patrick DL, Althof SE, Pryor JL, et al., Premature ejaculation: ejaculation, Curr Opin Investig Drugs, 2009;10:681.
ejaculation, Physiol Behav, 2004;83:203. an observational study of men and their partners, J Sex Med, 40. Hiemke C, Hartter S, Pharmacokinetics of selective
5. Giuliano F, Clement P, Serotonin and premature ejaculation: 2005;2:358. serotonin reuptake inhibitors, Pharmacol Ther, 2000;85:11.
from physiology to patient management, Eur Urol, 23. Pryor JL, Althof SE, Steidle C, et al., Efficacy and tolerability 41. Modi NB, Dresser MJ, Simon M, et al., Single- and multiple-
2006;50:454. of dapoxetine in treatment of premature ejaculation: an dose pharmacokinetics of dapoxetine hydrochloride, a
6. Hamson DK, Watson NV, Regional brainstem expression of integrated analysis of two double-blind, randomised novel agent for the treatment of premature ejaculation,
Fos associated with sexual behavior in male rats, controlled trials, Lancet, 2006;368:929. J Clin Pharmacol, 2006;46:301.
Brain Res, 2004;1006:233. 24. Waldinger MD, Lifelong premature ejaculation: from 42. Buvat J, Tesfaye F, Rothman M, et al., Dapoxetine for the
7. Heeb MM, Yahr P, Anatomical and functional connections authority-based to evidence-based medicine, BJU Int, treatment of premature ejaculation: results from a
among cell groups in the gerbil brain that are activated 2004;93:201. randomized, double-blind, placebo-controlled phase 3 trial
with ejaculation, J Comp Neurol, 2001;439:248. 25. Waldinger MD, Relevance of an evidence-based ejaculation in 22 countries, Eur Urol, 2009;55:957.
8. Meisel RL SB, The physiology of male sexual behavior. In: time cutoff point for neurobiological research of premature 43. Kaufman JM, Rosen RC, Mudumbi RV, et al., Treatment
Knobil E, Neil JD, The Physiology of Reproduction, 2nd edition, ejaculation, J Comp Neurol, 2005;493:46. benefit of dapoxetine for premature ejaculation: results
New York: Raven Press, 1994;3–105. 26. Giuliano F, Patrick DL, Porst H, et al., Premature ejaculation: from a placebo-controlled phase III trial, BJU Int,
9. Marson L, McKenna KE, The identification of a brainstem results from a five-country European observational study, 2009;103:651.
site controlling spinal sexual reflexes in male rats, Brain Res, Eur Urol, 2008;53:1048. 44. McMahon C, Park NC, Zhao Y, et al., Treatment of
1990;515:303. 27. Rosen RC, McMahon CG, Niederberger C, et al., Correlates premature ejaculation (PE) in the Asia-Pacific region:Results
10. Murphy AZ, Hoffman GE, Distribution of gonadal steroid to the clinical diagnosis of premature ejaculation: results from a phase III double-blind, pararel-group study of
receptor-containing neurons in the preoptic-periaqueductal from a large observational study of men and their partners, dapoxetine, Biennial Meeting of the Asia Pacific Society for
gray-brainstem pathway: a potential circuit for the initiation J Urol, 2007;177:1059. Sexual Medicine, 2007;05–06.
of male sexual behavior, J Comp Neurol, 2001;438:191. 28. Giuliano F, Patrick DL, Porst H, et al., Premature ejaculation: 45. Hellstrom WJ, Emerging treatments for premature
11. Marson L, Lesions of the periaqueductal gray block the results from a European observational study. Poster, ejaculation: focus on dapoxetine, Neuropsychiatr Dis Treat,
medial preoptic area-induced activation of the Annual Meeting of the European Association for Urology, 2009;5:37.
urethrogenital reflex in male rats, Neurosci Lett, 2004;367:278. 2006. 46. McMahon CG, Clinical trial methodology in premature
12. Olivier B, van Oorschot R, Waldinger MD, Serotonin, 29. Rowland D, Perelman M, Althof S, et al., Self-reported ejaculation observational, interventional, and treatment
serotonergic receptors, selective serotonin reuptake premature ejaculation and aspects of sexual functioning preference studies—part II—study design, outcome
inhibitors and sexual behaviour, Int Clin Psychopharmacol, and satisfaction, J Sex Med, 2004;1:225. measures, data analysis, and reporting, J Sex Med,
1998;13(Suppl. 6):S9. 30. Patrick DL RM, McNulty P, Jamieson C, et al., Can single 2008;5:1817.
13. Hillegaart V, Ahlenius S, Facilitation and inhibition of male items adequately capture outcomes of premature 47. Park NC, McMahon C, Tesfaye F, et al., Safety and
rat ejaculatory behaviour by the respective 5-HT1A and ejaculation (PE)?, J Urol, 2005;173(Suppl.):338. tolerability of dapoxetine fro the treatment of premature
5-HT1B receptor agonists 8-OH-DPAT and anpirtoline, as 31. Balon R, Antidepressants in the treatment of premature ejaculation in an Asia-Pacific population, Biennial Meeting
evidenced by use of the corresponding new and selective ejaculation, J Sex Marital Ther, 1996;22:85. of the Asia Pacific Society for Sexual Medicine, Jeju, Korea,
receptor antagonists NAD-299 and NAS-181, Br J Pharmacol, 32. Montague DK, Jarow J, Broderick GA, et al., AUA guideline 2007;11: abstract OS-05-07.
1998;125:1733. on the pharmacologic management of premature 48. McMahon C, Althof SE, Kaufman JM, et al., Efficacy and
14. Hull EM, Du J, Lorrain DS et al., Extracellular dopamine ejaculation, J Urol, 2004;172:290. safety of dapoxetine for premature ejaulation: Integrated
in the medial preoptic area: implications for sexual 33. Waldinger MD, Zwinderman AH, Olivier B, On-demand analysis of 5 phase III trials, J Sex Med, 2009;6: abstract
motivation and hormonal control of copulation, J Neurosci, treatment of premature ejaculation with clomipramine and PD-068.
1995;15:7465. paroxetine: a randomized, double-blind fixed- 49. Moore DP. Jefferson JW (eds), Selective serotonin reuptake
15. Filippi S, Vignozzi L, Vannelli GB, et al., Role of oxytocin in dose study with stopwatch assessment, Eur Urol, inhibitors. In: Handbook of Medical Psychiatry 2nd edition,
the ejaculatory process, J Endocrinol Invest, 2003;26:82. 2004;46:510. Philadelphia, PA: Mosby Inc., 2004;453–55.
16. Bitran D, Hull EM, Pharmacological analysis of male rat 34. McMahon CG, Treatment of premature ejaculation with 50. Casey R, Tesfaye F, Mudumbi R, et al., Effects of dapoxetine
sexual behavior, Neurosci Biobehav Rev, 1987;11:365. sertraline hydrochloride: a single-blind placebo controlled (DPX) for the treatment of premature ejaculation (PE) on
17. Giuliano F, Clement P, Physiology of ejaculation: emphasis crossover study, J Urol, 1998;159:1935. the erectile function and scales of mood and affect, Eur Urol
on serotonergic control, Eur Urol, 2005;48:408. 35. McMahon CG, Touma K, Treatment of premature Suppl, 2008;7(3): abstract 463.
18. Waldinger MD, Berendsen HH, Blok BF, et al., Premature ejaculation with paroxetine hydrochloride, Int J Impot Res, 51. Giuliano F, Levine SB, Buvat J, et al., Lack of withdrawal
ejaculation and serotonergic antidepressants-induced 1999;11:241. syndrome or effects on anxiety with dapoxetine (DPX) for
delayed ejaculation: the involvement of the serotonergic 36. Lane R, Baldwin D, Selective serotonin reuptake the treatment of premature ejaculation (PE): Results from
system, Behav Brain Res, 1998;92:111. inhibitor-induced serotonin syndrome: review, J Clin phase III trials, Eur Urol Suppl, 2008;7: abstract 465.
72
EUROPEAN UROLOGICAL REVIEW
Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72  |  Page 73  |  Page 74  |  Page 75  |  Page 76  |  Page 77  |  Page 78  |  Page 79  |  Page 80  |  Page 81  |  Page 82  |  Page 83  |  Page 84  |  Page 85  |  Page 86  |  Page 87  |  Page 88  |  Page 89  |  Page 90  |  Page 91  |  Page 92  |  Page 93  |  Page 94  |  Page 95  |  Page 96  |  Page 97  |  Page 98  |  Page 99  |  Page 100