Pugliatti_EU Neurology 09/03/2010 13:25 Page 124
International Health
limited to small samples of patients and might preclude inferences
to the general target population. Most of the reported health Maura Pugliatti is a Neurologist and Assistant Professor of
economic studies do not include indirect nor intangible costs. Also,
Neurology in the Department of Neurosciences at the
University of Sassari in Italy. Her scientific work is
due to co-morbidity, allocating patients to different groups of
characterised by high-quality international research in the
disorders can be problematic, and double-counting of costs may be field of multiple sclerosis (MS). Within the European Brain
underestimated. If cost studies are incidence-based, they cover only
Council she has provided specific expertise for the Panel
of Epidemiology of MS, ultimately aimed at estimating the
the first year with disease, which is generally the most expensive.
socioeconomic burden of the disease in Europe.
For age-related conditions such as dementia and stroke,
Paola Cossu is a Neurologist and Research Fellow in the
recruitment of elderly populations is complex and potentially
Department of Neurosciences at the University of Sassari
in Italy. She collaborates with Dr Pugliatti and international
affected by selection bias, as individuals are more easily enrolled
teams of highly qualified researchers in the field of
from institutions.
15
On the other hand, severe cognitive disorders
neuroepidemiology and public health with regard to
and old age may lead to higher refusal rates, interfering with the
multiple sclerosis and epilepsy.
health economic assessment. Epidemiological and cost data on
child-related disorders are especially scarce.
Ettore Beghi is Head of the Laboratory of Neurological
Conclusions
Disorders at the ‘Mario Negri’ Institute in Milan. He is
an active member of many scientific associations, for
Due to the ageing of the Italian population, the socioeconomic
which he has also held leadership roles. He is an
burden of brain diseases is expected to increase remarkably. Associate Editor of Epilepsia, sits on the Editorial Board of
Qualified research is needed in this field using prospective designs
Neuroepidemiology, Clinical Neurology & Neurosurgery,
Inpharma and Clinical Drug Investigation and is a reviewer
and standardised screening instruments in order to obtain
for many other journals. Dr Beghi is the author of more
comparable epidemiological and cost data at a national and than 300 scientific publications.
international level. n
1. Olesen J, Leonardi M, The burden of brain diseases in heavy drinking: a survey in three italian villages, Alcohol drug use and drug use disorders in EU countries and
Europe, Eur J Neurol, 2003;10:471–7. Alcohol, 2006; 41(3):336–40. Norway: an overview of the epidemiology, Eur
2. Drummond M, Principles of economic appraisal in health care, 11. Scafato E, Epidemiologia dell’alcol e del mondo femminile, Neuropsychopharmacol, 2005;15:389–97.
Oxford University Press, 1980. Ann Ist Super Sanità, 2004;40(1):25–33. 20. Paykel ES, Brugha T, Fryers T, Size and burden of
3. Andlin-Sobocki P, Jönsson B, Wittchen HU, Olesen J, Cost 12. World Health Organization (WHO), Alcohol policies in depressive disorders in Europe, Eur Neuropsychopharmacol,
of disorders of the brain in Europe, Eur J Neurol, Europe, In: Alcohol in the European Region consumption, harm 2005;15:411–23.
2005;12(Suppl. 1):1–27. and policies, Nina Rehn and the National Counterparts of 21. Pini S, de Queiroz V, Pagnin D, et al., Prevalence and
4. Pugliatti M, Sobocki P, Beghi E, et al., Cost of Disorders of European Alcohol Action Plan, 2001:43–76. burden of bipolar disorders in European countries,
the Brain in Europe Study Group. Cost of disorders of the 13. Gerzeli S, Tarricone R, Zolo P, et al, The economic burden Eur Neuropsychopharmacol, 2005;15:425–34.
brain in Italy, Neurol Sci, 2008;29:99–107. of stroke in Italy. The EcLIPSE Study: Economic 22. Lieb R, Becker E, Altamura C, The epidemiology of
5. Sobocki P, Jönsson B, Angst J, Rehnberg C, Cost of Longitudinal Incidence-based Project for Stroke generalized anxiety disorder in Europe, Eur
depression in Europe, J Ment Health Policy Econ, Evaluation, Neurol Sci, 2005;26:72–80. Neuropsychopharmacol, 2005;15:445–52.
2006;9:87–98. 14. Gioia V, Traumi gravi, ecco i costi delle cure hub&spoke I, 23. Forsgren L, Beghi E, Õun A, Sillanpää M, The epidemiology
6. Ekman M, Westphal M, Cost of brain tumour in Europe, Il Sole 24 Ore, 20-26 set, 2005:22–3. of epilepsy in Europe – a systematic review, Eur J Neurol,
Eur J Neurol, 2005;12(Suppl. 1):45–9. 15. Berr C, Wancata J, Ritchie K, Prevalence of dementia in the 2005;12:245–53.
7. Wittchen HU, Jacobi F, Size and burden of mental elderly in Europe, Eur Neuropsychopharmacol, 2005;15:463–71. 24. Stovner LJ, Zwart J-A, Hagen K, et al., Epidemiology of
disorders in Europe – a critical review and appraisal of 16. Rehm J, Room R, van den Brink W, Jacobi F, Alcohol use headache in Europe, Eur J Neurol, 2006;13:333–45.
27 studies, Eur Neuropsychopharmacol, 2005;15:357–76. disorders in EU countries and Norway: An overview of the 25. Pugliatti M, Rosati G, Carton H, et al., The epidemiology of
8. Garattini L, Barbui C, Clemente R, et al., On behalf of the epidemiolgy, Eur Neuropsychopharmacol, 2005;15:377–88. multiple sclerosis in Europe, Eur J Neurol, 2006;13:700–22.
Study Group SCORE. Direct Costs of Schizophrenia and 17. Alonso J, Ferrer M, Romera B et al., The European Study of 26. Granieri E, Casetta I, Govoni V, et al., The increasing
Related Disorders in Italian Community Mental Health the Epidemiology of Mental Disorders (ESEMeD/MHEDEA incidence and prevalence of MS in a Sardinian province,
Services: A Multicenter, Prospective 1-Year Follow-up 2000) project. Rationale and methods, Int J Meth Psychiatr Neurology, 2000;55:842–7.
Study, Schizophrenia Bulletin, 2004;30:295–302. Res, 2002;11:55–67. 27. von Campenhausen S, Bornschein B, Wick R, et al.,
9. Battaglia A, Dubini A, Mannheimer R, Pancheri P, 18. Alonso J, Angermeyer MC, Bernert S, et al., Prevalence of Prevalence and incidence of Parkinson’s disease in
Depression in the Italian community: epidemiology and mental disorders in Europe: Results from the European Europe, Eur Neuropsychopharmacol, 2005;15:473–90.
socio-economic implications, Int Clin Psychopharmacol, Study of the Epidemiology of Mental Disorders (ESEMeD) 28. Truelsen T, Piechowski-Jozwiak B, Bonita R, et al., Stroke
2004;19:135–42. project, Acta Psychiatr Scand, 2004;(Suppl.):21–7. incidence and prevalence in Europe: a review of available
10. Guerrini I, Gentili C, Guazzelli M, Alcohol consumption and 19. Rehm J, Room R, van den Brink W, Kraus L, Problematic data, Eur J Neurol, 2006;13:581–98.
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