Ferro_Eu Neuro Rev_EU Neurology 08/03/2010 16:11 Page 41
Subarachnoid Haemorrhage – Current Thinking and Future Strategy
advances, these will pose some difficulties in being evaluated by Finally, we need more prospective studies on life after SAH, exploring
clinical trials because by the time the evaluation is complete, the ‘soft’ end-points (cognition, behaviour, sleep, ability to return to work,
technology will probably be obsolete. etc.) and quality of life, which are neglected in many prognostic
studies conducted in SAH survivors. n
Concerning the best modality of ruptured aneurysm treatment, longer
follow-up of large series of patients treated by coiling is needed to
José M Ferro is a Full Professor and Director of the
ensure long-term completeness of aneurysm exclusion and risk
Neurosciences Department at Santa Maria Hospital,
of re-bleeding. Studies addressing cost-effectiveness issues of University of Lisbon. He is President of the European
intracranial aneurysm treatment are also needed. The safety of stent-
Neurological Society (ENS) and a member of the
Executive Committee of the European Stroke
assisted coil embolisation and of all other innovations in endovascular
Organisation and of the Programme Committee of the
treatment should be evaluated before they are disseminated. European Stroke Conference. He has authored 176
publications in peer-reviewed journals. He received his
medical training and PhD at the University of Lisbon.
Preventing and treating vasospasm is a challenge for the near future.
Statins are a promising therapy.
71,72
Nicardipine prolonged-release
Patricia Canhão is an Invited Professor at the University
implants,
73
nitric oxide donors, proteinase-activated receptor-1
of Lisbon, and a Graduate Neurologist Assistant and
antagonists,
74
endothelin antagonists,
75
potassium-channel activators
Consultant at Santa Maria Hospital and Fellow of the
and magnesium
76
are among the drugs and classes of drugs yet to be
European Stroke Organisation. She has authored 44
publications and eight book chapters and has
evaluated in randomised clinical trials. Intra-arterial mechanical and
collaborated in several international collaborative
pharmachological interventions to treat vasospasm and intracisternal
studies. Dr Canhão undertook her medical training at
thrombolytics also need to be evaluated by adequately powered
the University of Lisbon.
randomised clinical trials.
1. Linn FH, Rinkel GJE, van Gijn J, Stroke, 1996;27:625–9. 2003;60:208–14. 51. Egge A, Waterloo K, Sjøholm H, et al., Neurosurgery,
2. The ACROSS Group, Stroke, 2000;1843–50. 29. Byrne JV, Boardman P, Ioannidis I, et al., Neurosurgery, 2001;49:593–605.
3. Feigin VL, Rinkel GJE, Lawes CM, et al., Stroke, 2003;52:545–52. 52. Amin-Hanjani S, Ogilvy CS, Barker FG, Neurosurgery,
2005;36:2773–80. 30. Kreitschmann-Andermahr I, Hoff C, Saller B, et al., J Clin 2004;54:326–34.
4. McCarron MO, Alberts MJ, McCarron P, J Neurol Neurosurg Endocrinol Metab, 2004;89:4986–92. 53. Dalbasti T, Karabiyikoglu M, Ozdamar N, et al., J Neurosurg,
Psychiatry, 2004;75:491–3. 31. Schuiling WJ, Rinkel GJE, Walchenbach R, et al., Stroke, 2001;95:44–50.
5. Caeiro L, Menger C, Ferro JM, et al., Cerebrovasc Dis, 2005;36:578–82. 54. Thomas JE, McGinnis G, Stroke, 2002;33:486–92.
2005;19:31–8. 32. Molyneux A, Kerr R, Stratton I, et al., Lancet, 55. Feigin VL, Anderson N, Rinkel GJ, et al., Cochrane Database
6. Casetta I, Granieri E, Am J Emerg Med, 2004;22:227–8. 2002;360:1267–74. Syst Rev, 2005;3:CD004583.
7. Polmear A, Cephalalgia 2003;23:935–41. 33. Koivisto T, Vanninen R, Hurskainen H, et al., Stroke, 56. Nieuwkamp DJ, de Gans K, Rinkel GJ, et al., J Neurol,
8. Landtblom A-M, Fridriksson S, Boivie J, et al., Cephalagia, 2000;31:2369–77. 2000;247:117–21.
2002;22:354–60. 34. Molyneux AJ, Kerr RSC, Yu L-M, et al.; for the International 57. Ballard J, Kreiter KT, Claassen J, et al., Stroke,
9. Liebenberg WA, Worth R, Firth GB, et al., Postgrad Med J, Subarachnoid Aneurysm Trial (ISAT) Collaborative Group, 2003;34:1859–63.
2005;81:470–73. Lancet, 2005;366:809–17. 58. Bor AS, Rinkel GJ, Adami J, et al., Brain, 2008;131
10. Byyny RL, Mower WR, Shum N, et al., Ann Emerg Med, 35. Johnston SC, Higashida RT, Barrow DL, et al., Stroke, (Pt 10):2662–65.
2008;51:697–703. 2002;33:2536–44. 59. Koffijberg H, Buskens E, Algra A, et al., J Neurosurg,
11. Beetham R, J Neurol Neurosurg Psychiatry, 2004;75:528. 36. Lozier AP, Connoly ES, Lavine SD, et al., Stroke, 2008;109:176–85.
12. Perry JJ, Spacek A, Forbes M, et al., Ann Emerg Med, 2002;33:2509–18. 60. Aoki T, Kataoka H, Moriwaki T, et al., Stroke,
2008;51:707–13. 37. De Gans K, Nieuwkamp DJ, Rinkel GJ, Algra A, Neurosurgery, 2007;38:2337–45.
13. Wardlaw JM, White PM, Brain, 2000;123(Pt 2):205–21. 2002;50:336–40. 61. Foroud T, Sauerbeck L, Brown R, et al., Stroke,
14. van Gelder JM, Neurosurgery, 2003;53(3):597–605. 38. Ohman J, Heiskanen O, J Neurosurg, 1989;70:55–60. 2008;39:1434–40.
15. van Gijn J, van Dongen Vermeulen M, et al., Neurology, 39. Whitfield PC, Kirkpatrick PJ, Cochrane Database Syst Rev, 62. Ruigrok YM, Rinkel GJE, Wijmenga C, Lancet Neurol,
1985;35:493–7. 2001;2:CD001697. 2005;4:179–89.
16. Katoh M, Yoshino M, Asaoka K, et al., Surgical Neurology, 40. van der Schaaf I, Algra A, Wermer M, et al., Cochrane 63. Zhang J, Claterbuck RE, Int J Stroke 2008;3:272–87.
2007;68:457–60. Database Syst Rev, 2005;4:CD003085. 64. Ruigrok YM, Rinkel GJ, Stroke, 2008;39:1049–55.
17. Naidech AM, Janjua N, Kreiter KT, et al., Arch Neurol, 41. Wilby MJ, Sharp M, Whitfield PC, et al., Stroke, 65. Bor AS, Velthuis BK, Majoie CB, et al., Neurology,
2005;62:410–16. 2003;34:2508–11. 2008;70:700–705.
18. Hijdra A, Braakman R, va Djin J, et al., Stroke, 1987;18:1061–7. 42. Ross Y, Rinkel G, Vermeulen M, et al., Stroke, 66. Wermer MJH, Buskens E, van der Schaaf, et al., Neurology,
19. Winn HR, Richardson AE, Jane JA, Ann Neurol, 2003;34:2308–9. 2004;62:369–75.
1977;1:358–70. 43. Dorhout Mees SM, van den Bergh, Algra A, et al., Stroke, 67. Wermer MJ, Koffijberg H, van der Schaaf IC; Neurology,
20. Lysakowski C, Walder B, Costanza MC, et al., Stroke, 2008;39:2186–7. 2008;70:2053–62.
2001;32:2292–8. 44. Mees SMD, Rinkel GJE, Feigin V, et al., Stroke, 68. Mitchell P, Gholkar A, Vindlacheruvu RR, et al., Lancet Neurol,
21. Macrea LM, Tramer MR, Walder B, Resuscitation, 2008;39:514–15. 2004;3:85–92.
2005;65:139–48. 45. Siironen J, Juvela S, Varis J, et al., J Neurosurg, 69. Pierot L, Spelle L, Vitry F; Stroke, 2008;39:2497–2504.
22. Sakr YL, Ghosn I, Vincent JL, Prog Cardiovasc Dis, 2003;99:953–9. 70. Linfante I, Wakhloo AK, Stroke, 2007;38:1411–17.
2002;45:67–80. 46. Jang YG, Ilodigwe D, Macdonald RL, Neurocrit Care, 71. Tseng M-Y, Czosnyka M, Richards H, et al., Stroke, 2005;36:
23. van Heuven AW, Dorhout Mees SM, Algra A, et al., Stroke, 2009;10(1):141–7. 1627–32.
2008;39:1347–8. 47. Zwienenberg-Lee M, Hartman J, Rudisill N, et al., Stroke 72. Sillberg VA, Wells GA, Perry JJ, Stroke, 2008;39:2622–6.
24. Rosen DS, MacDonald RL, Neurocrit Care, 2005;2:110–18. 2008;39:1759–65. 73. Kasuya H, Onda H, Sasahara A, et al., Neurosurgery,
25. Clarke G, Mendelow AD, Mitchell P, Acta Neurochir (Wein), 48. Lee KH, Lukovits T, Friedman JA, Neurocrit Care, 2005;56:895–902.
2005;147:259–63. 2006;4:68–76. 74. Kai Y, Hirano K, Maeda Y, et al., Stroke 2007;38:3259–65.
26. Rosengart AJ, Schultheiss KE, Tolentino J, et al., Stroke, 49. Treggiari MM, Walder B, Suter PM, et al., J Neurosurg, 75. Vajoczy P, Meyer B, Weidauer S, et al., J Neurosurg,
2007;38:2315–21. 2003;98:978–84. 2005;103:9–17.
27. Hop JW, Rinkel GJE, Algra A, et al., Stroke, 1997;28:660–64. 50. Rinkel GJ, Feigin VL, Algra A, et al., Cochrane Database Syst 76. van der Bergh WM, Algra A, van Kooten F, et al., Stroke
28. Claassen J, Peery S, Kreiter KT, et al., Neurology, Rev, 2004;18(4):CD000483. 2005;36:1011–15.
EUROPEAN NEUROLOGICAL REVIEW 41
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