Supportive Oncology
Figure 3: Acneiform Eruption Before and After Treatment
A
A: Acneiform eruption induced by cisplatinum + cetuximab regimen after one month of treatment
Figure 4: Deep Heel Fissures on Right Foot Before and After Treatment
A
A: Deep heel fissures on right foot induced by cetuximab + carboplatin regimen over six months
B
B: Result after one week of topical treatment with Evozac Solution spray twice a day
B
B: Result after two weeks of topical treatment with Evoskin spray (for (two days) and then Evoskin Gel cream twice a day.
C
C: Result after 26 days with the same regimen
Case Report 3
The final case report summarises the clinical benefits obtained after using the Evoskin spray, which is specially formulated for hand–foot syndrome experienced during chemotherapy with cetuximab. A 49- year-old man presented with deep heel fissures on both feet with pronounced hyperkeratosis and significant discomfort when applying pressure to the heel (see Figure 4A). He had been treated for cancer of the right maxillary sinus by the combination of carboplatine and cetuximab (Erbitux) for six months.
In order to reduce the fissures, Evoskin Solution Spray was sprayed on the heels morning and night for the first two days, then Evoskin Gel Cream was applied as a follow-up at the same dosage. Evoskin Solution Spray and Gel Cream are formulated from mineral elements contained in Evaux thermal spring water (lithium, manganese, strontium). Two weeks after starting application of Evoskin, the fissures were closing and their haemorrhagic nature had disappeared, and the discomfort under pressure had eased (see Figure 4B). No intolerance to ungual Evoskin Solution Spray and Gel Cream was reported by the patient during the application period.
1. Wasner G, Hilpert F, Schattschneider J, et al., Docetaxel- induced nail changes – a neurogenic mechanism: a case
report, J Neur Oncol, 2002;58:167–74.
Cetuximab (Erbitux), an EGF receptor inhibitor, is a frequently used chemotherapeutic agent, especially in the treatment of ENT cancers expressing this receptor. The incapacitating fissured conditions induced by this molecule are often reported in the literature. The introduction of an effective product without side effects for topical use in a rapid timespan of several days for resolution of heel fissures observed during chemotherapy offers the patient a significant functional and aesthetic benefit by improving his or her quality of life and contributing to better adherence to the chemotherapy regimen.
Conclusion
By underlining the involvement of neuromediators in cutaneous problems, particularly following chemotherapy, Evolife Laboratories offers complete, specific and innovative solutions for cutaneous and muco-cutaneous side effects induced by chemotherapy. n
Jean-François Chanez is Head of the Scientific Department at Evolife Laboratoires, which develops innovative products based on the properties of Evaux thermal spring water and micro-algae growing in it, especially in the fields of dermatology and oncology (supporting care). He has had a long career in the pharmaceutical and cosmetic industries, and has managed the research and development departments of several companies. After graduating, he began work on skin pharmacokinetics with
special emphasis on percutaneous absorption of drugs, especially in transdermal delivery systems. Dr Chanez received his PhD from the School of Pharmacy at Paris XI and received a prize from the National Academy of Pharmacy for his research projects.
2. Boisnic S, Branchet MC, Chanez JF, Evaluation of the inhibition of human sébocytes proliferation stimulated by substance P and corticotropin-releasing hormone by
mineral constituents in Evaux thermal spring water, Nouv Dermatol, 2004;23:569–75.
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