Contents

Foreword

Leonard Girnita

Associate Professor of Pathology, Department of Oncology/Pathology, Karolinska Institute

Current Issues

Novel Therapies

Survivin-directed Anticancer Therapies – A Review of Pre-clinical Data and Early-phase Clinical Trials

Helen Doolittle,1

Armand Morel2 and Denis Talbot3

1. Researcher, North West Thames Academic Foundation Programme, Hammersmith Hospital, Imperial College, London; 2. Clinical Research Assistant, Oxford Lung Cancer Group, Churchill Hospital, University of Oxford; 3. Consultant Medical Oncologist, and Reader, Oxford Cancer Centre, University of Oxford

Cancer Prevention

Budesonide versus Placebo in a High-risk Population with Screen-detected Lung Nodules

Matteo Lazzeroni,1

Giulia Veronesi2 and Bernardo Bonanni3

1. Medical Oncology Resident, Division of Cancer Prevention and Genetics; 2. Director, Lung Cancer Early Detection Unit, Department of Thoracic Surgery; 3. Director, Division of Cancer Prevention and Genetics, European Institute of Oncology

Supportive Oncology

The Use of Patient-reported Outcomes at an Individual Level – Benefits and Challenges

Agnes Czimbalmos1

and Andrew Bottomley2

1. Research Fellow; 2. Assistant Director and Head, Quality of Life Department, European Organisation for Research and Treatment of Cancer

Local Control of Metastatic Spinal Cord Compression Following Radiotherapy

Dirk Rades1

and Steven E Schild2

1. Vice Chairman, and Full Professor of Radiation Oncology, Department of Radiation Oncology, University of Lubeck; 2. Chairman, and Professor, Department of Radiation Oncology, Mayo Clinic Arizona

The Neurogenic Component of Cutaneous Toxicities Induced by Chemotherapy – New Solutions

Jean-François Chanez

Head, Scientific Department, Evolife Laboratoires

Fertility Preservation Options for Patients with Cancer

Melissa C Hulvat1

and Jacqueline S Jeruss2

1. Breast-surgical Oncologist, and Co-Director, Bass Breast Center, Northwest Healthcare; 2. Assistant Professor, and Course Director, Surgical Ethics, Department of Surgery, Robert H Lurie Comprehensive Cancer Center and Lynn Sage Comprehensive Breast Center, Northwestern University Feinberg School of Medicine

Breast Cancer

Evolution of the 21-gene Assay Oncotype DX® from an Experimental Assay to an Instrument Assisting in Risk Prediction and Optimisation of Treatment Decision-making in Early Breast Cancer

Christian Jackisch,1

Michael Untch,2 Jens-Uwe Blohmer,3 Ulrike Nitz4 and Nadia Harbeck5

1. Professor of Gynaecology, and Head, Department of Obstetrics and Gynaecology and Breast Cancer Centre, Klinikum Offenbach; 2. Professor of Gynaecology, and Head, Department of Obstetrics and Gynaecology and Interdisciplinary Breast Cancer Centre, Helios Klinikum Berlin-Buch; 3. Professor of Gynaecology, and Head, Department of Obstetrics and Gynaecology and Breast Cancer Centre, Sankt Gertrauden Hospital, Berlin; 4. Professor of Gynaecology, and Head, Department of Senology, Bethesda Krankenhaus, Mönchengladbach; 5. Professor of Gynaecology, and Head, Breast Centre, University of Cologne

Head and Neck Cancer

Targeted Therapy in Combination with Chemotherapy in Recurrent and/or Metastatic Head and Neck Cancer

Pol Specenier1

and Jan B Vermorken2

1. Medical Oncologist; 2. Professor of Oncology, and Head, Department of Medical Oncology, Antwerp University Hospital

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