Contents Foreword Arthur W Toga Professor of Neurology, University of California, Los Angeles Neurodegenerative Disease


Genetics and Molecular Biology of Alzheimer’s Disease and Frontotemporal Lobar Degeneration Daniela Galimberti,1


Chiara Fenoglio1 and Elio Scarpini2


1. PhD Researcher; 2. Professor of Neurology, Department of Neurological Science, ‘Dino Ferrari’ Centre, University of Milan


Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease Paula I Moreira


Researcher, Faculty of Medicine and Centre for Neuroscience and Cell Biology, University of Coimbra


Continuous Dopaminergic Stimulation in Parkinson’s Disease – What Have We Learned from Positron-emission Tomography?


David J Brooks1 and Nicola Pavese2


1. Hartnett Professor of Neurology, and Head, Centre for Neuroscience, Department of Medicine, Imperial College London; 2. Senior Investigator Scientist, Medical Research Council – Neurology PET Group, and Honorary Senior Lecturer, Imperial College London


Olfactory Function in Parkinson’s Disease Antje Haehner,1


Thomas Hummel2 26 and Heinz Reichmann3


1. Assistant Professor, Department of Otorhinolaryngology and Department of Neurology; 2. Professor, Department of Otorhinolaryngology; 3. Professor of Neurology, Department of Neurology, University of Dresden Medical School


Genetic Insights into Early-onset Parkinson’s Disease Roy N Alcalay1


and Cheryl Waters2


1. Assistant Professor; 2. Albert B and Judith L Glickman Professor, Division of Movement Disorders, Department of Neurology, Columbia University Medical Center


Brain Trauma


‘Infectious Burden’ – New Insights into Stroke Prevention Jorge M Luna1


and Mitchell SV Elkind2


1. Graduate Research Assistant, and Doctoral Candidate; 2. Associate Professor of Neurology, Associate Chairman of Neurology, and Associate Professor of Epidemiology, Columbia University College of Physicians and Surgeons and Joseph Mailman School of Public Health, Columbia University


Post-stroke Infections – Diagnosis, Prediction, Prevention and Treatment to Improve Patient Outcomes


Hendrik Harms,1 Elke Halle2 and Andreas Meisel3


1. Clinical Scientist, Centre for Stroke Research Berlin, and Attending Neurologist, Department of Neurology, Charité Medical University Berlin; 2. Clinical Scientist, and Attending Microbiologist, Institute for Microbiology and Hygiene; 3. Professor of Neurology, NeuroCure Clinical Research Centre and Centre for Stroke Research Berlin, and Attending Physician, and Neurointensivist, Department of Neurology, Charité Medical University Berlin


Transient Ischaemic Attack – Obtaining a Differential Diagnosis and Predicting Patient Risk Matthew F Giles


Consultant Physician, and Geriatrician, John Radcliffe Hospital, and Senior Research Fellow, Stroke Prevention Research Unit, NIHR Biomedical Research Centre, Oxford University


Advances in Treatment Options for High-grade Glioma – Current Status and Future Perspectives Ryan T Merrell,1


Eudocia C Quant2 and Patrick Y Wen2,3


1. Neuro-oncology Fellow; 2. Neuro-oncologist; 3. Professor of Neurology, and Director, Center for Neuro-oncology, Dana Farber/Brigham and Women’s Cancer Center, and Division of Neuro-oncology, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School


Multiple Sclerosis


Disease Progression in Multiple Sclerosis I. Impaired Mobility and Its Impact on Limitations of Activities and Social Participation


Jürg Kesselring


Head, Department of Neurology and Neurorehabilitation, Rehabilitation Centre, Valens, and Professor of Clinical Neurology and Neurorehabilitation, University of Bern and Neuroscience Centre, Zürich


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EUROPEAN NEUROLOGICAL REVIEW


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