This page contains a Flash digital edition of a book.
US Neurology Volume 6 • Issue 2


Coloured magnetic resonance imaging (MRI) scans of a healthy brain. © Pasieka/Science Photo Library


Managing Editor Tami Hughes


Sub-editorial Manager Lisa Glass


Senior Sub-editor Claire Vinent


Technical Editors Patrick Wong James Gilbart Saira Ansari


Design Manager Eliza Albie


Artworker Aiza Cheung


Production Manager Anthony Gibbons


Production Co-ordinator Frances Lee


Key Account Director Tim Sheldrick


Senior Account Manager Matthew Goodwin


Medical Sales Director Barney Kent


Publishing Director Fergus Brunning


Editorial Contact Tami Hughes


T: +44 (0) 20 7452 5232 F: +44 (0) 20 7452 5050


E: tami.hughes@touchbriefings.com


Circulation Contact Miriam Oppenheim


E: miriam.oppenheim@touchbriefings.com


Sales Contact Matthew Goodwin T: +44 (0) 20 7452 5361 F: +44 (0) 20 7452 5606


E: matthew.goodwin@touchbriefings.com


Association Contact Xue Han


T: +44 (0) 20 7452 5042 F: +44 (0) 20 7452 5606


E: xue.han@touchbriefings.com US Neurology is audited by BPA Worldwide. Published by Touch Briefings. Touch Briefings is the trading name of Business Briefings Ltd, a Touch Group plc company.


All information obtained by Business Briefings Ltd and each of the contributors from various sources is as current and accurate as possible. However, due to human or mechanical errors, Business Briefings Ltd and the contributors cannot guarantee the accuracy, adequacy or completeness of any information, and cannot be held responsible for any errors or omissions, or for the results obtained from the use thereof.


Where opinion is expressed, it is that of the authors and does not necessarily coincide with the editorial views of Business Briefings Ltd. Statistical and financial data in this publication have been compiled on the basis of factual information and do not constitute any investment advertisement or investment advice.


©2010 All rights reserved ISSN: 1758-1435 US Neurology wishes to thank the organizations below for their assistance. This does not constitute any official endorsement.


Francois Bethoux, MD Director, Rehabilitation Services, Mellen Center for Multiple Sclerosis, The Cleveland Clinic


Jeffrey L Cummings, MD Director, Cleveland Clinic Lou Ruvo Center for Brain Health


Gary Cutter, PhD Professor of Biostatistics, University of Alabama at Birmingham


Robert M Friedlander, MD Professor and Chairman, Neurological Surgery, University of Pittsburgh


William Friedman, MD Professor and Chairman, Department of Neurosurgery, University of Florida


Anthony J Furlan, MD Professor and Chairman, Department of Neurology, Case Western Reserve University


Vincent Gattullo


Executive Committee, American Parkinson's Disease Association


Peter J Goadsby, MD


Professor of Neurology, University of California, San Francisco


James C Grotta, MD


Professor of Neurology, University of Texas Medical School at Houston


David A Hafler, MD Professor of Neurology and Immunobiology, Yale School of Medicine


Daniel F Hanley, MD


Professor, Acute Care Neurology, Johns Hopkins University


Editorial Board


Rosalind Kalb, PhD Vice President, Professional Resource Center, National Multiple Sclerosis Society


Carlos S Kase, MD Chief of Neurology, Boston University School of Medicine


John J Kelly, MD


Professor of Neurology, George Washington University


Ruben I Kuzniecky, MD Professor and Co-Director, NYU Comprehensive Epilepsy Center


Fred D Lublin, MD


Saunders Family Professor of Neurology, Mount Sinai School of Medicine


Laura Marsh, MD


Head, Mental Health Care Line, Michael E DeBakey VA Medical Center


Michael S Okun, MD


Co-director, University of Florida Movement Disorders Center, McKnight Brain Institute


C Warren Olanow, MD


Professor, Departmentof Neurology, Mount Sinai School of Medicine


George Perry, PhD


Dean and Professor, College of Sciences, University of Texas at San Antonio


George B Richerson, MD, PhD Professor and Chairman, Neurology, The University of Iowa


Donald Schomer, MD


Professor of Neurology, Beth Israel Deaconess Medical Center, and Harvard Medical School


Steven S Schreiber, MD Professor, Department of Neurology, University of California, Irvine


Michael Schulder, MD Associate Professor of


Neurosurgery, University Hospital, New Jersey Medical School


Stephen D Silberstein, MD Professor of Neurology, Jefferson Headache Center, Thomas Jefferson University


Stewart J Tepper, MD


Professor and Director of Research, Center for Headache and Pain, Cleveland Clinic


Arthur Toga, PhD


Professor of Neurology, Laboratory of Neuro Imaging, University of California, Los Angeles


Steven U Walkley, DVM, PhD Professor, Department of Neuroscience, Pathology, and Neurology, Albert Einstein College of Medicine


Cheryl Waters, MD, FRCP(C) Professor, Division of Movement Disorders, Columbia University Medical Center


William J Weiner, MD Professor and Chairman of Neurology, University of Maryland


Patrick Y Wen, MD Neuro-oncologist, Dana Farber/Brigham and Women’s Cancer Center


G Frederick Wooten, MD Professor and Chairman, Department of Neurology, University of Virginia


US Neurology acknowledges the financial assistance of the following companies in the publication of this edition: 3m Healthcare, Acorda Therapeutics, Inc., Bioness, Inc., Genzyme Corporation, Innovative Neurotronics, Inc., Neuronetrix, Inc., and Teva Neuroscience.


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72  |  Page 73  |  Page 74  |  Page 75  |  Page 76  |  Page 77  |  Page 78  |  Page 79  |  Page 80  |  Page 81  |  Page 82  |  Page 83  |  Page 84  |  Page 85  |  Page 86  |  Page 87  |  Page 88  |  Page 89  |  Page 90  |  Page 91  |  Page 92  |  Page 93  |  Page 94  |  Page 95  |  Page 96  |  Page 97  |  Page 98  |  Page 99  |  Page 100  |  Page 101  |  Page 102  |  Page 103  |  Page 104  |  Page 105  |  Page 106  |  Page 107  |  Page 108  |  Page 109  |  Page 110  |  Page 111  |  Page 112  |  Page 113  |  Page 114  |  Page 115  |  Page 116  |  Page 117  |  Page 118  |  Page 119  |  Page 120  |  Page 121  |  Page 122  |  Page 123  |  Page 124  |  Page 125  |  Page 126  |  Page 127  |  Page 128  |  Page 129  |  Page 130  |  Page 131  |  Page 132