Developments in Transcatheter Heart Valves for Patients with Severe Aortic Stenosis Conclusion
TAVI has become a viable option for treatment of patients with severe symptomatic aortic valve stenosis. Current developments are promising to facilitate the TAVI procedure technically and improve procedural safety, thereby improving patient outcomes. Miniaturisation of catheter devices and sheaths will allow the treatment of more patients via the transfemoral route. Retrievable
1. Cribier A, Eltchaninoff H, Bash A, et al., Percutaneous transcatheter implantation of an aortic valve prosthesis for calcific aortic stenosis: first human case description, Circulation, 2002;106(24):3006–8.
2. Grube E, Laborde JC, Zickmann B, et al., First report on a human percutaneous transluminal implantation of a self- expanding valve prosthesis for interventional treatment of aortic valve stenosis, Catheter Cardiovasc Interv, 2005;66(4):465–9.
3. Thomas M, Schymik G, Walther T, et al., Thirty-day results of the SAPIEN aortic bioprosthesis european outcome (SOURCE) Registry: A European registry of transcatheter aortic valve
and repositionable valve systems will improve acute functional and haemodynamic valve results and presumably improve valve durability, which will be of great importance once the indication for TAVI is broadened to include younger patients and fewer high-risk patients. In all patients, prevention of periprocedural embolic stroke is of utmost importance and current developments of embolic deflectors are promising to improve patient safety. n
implantation using the Edwards SAPIEN valve, Circulation, 2010;122(1):62–9.
4. Kahlert P, Al-Rashid F, Weber M, et al., Vascular access site complications after percutaneous transfemoral aortic valve implantation, Herz, 2009;34(5):398–408.
5. Van Mieghem NM, Nuis RJ, Piazza N, et al., Vascular complications with transcatheter aortic valve implantation using the 18 Fr Medtronic CoreValve System: the Rotterdam experience, EuroIntervention, 2010;5(6):673–9.
6. Buellesfeld L, Gerckens U, Grube E, Percutaneous implantation of the first repositionable aortic valve prosthesis in a patient
with severe aortic stenosis, Catheter Cardiovasc Interv, 2008;71(5):579–84.
7. Treede H, Thilo T, Reichenspurner H, et al., Six-month results of a repositionable and retrievable pericardial valve for transcatheter aortic valve replacement: The Direct Flow Medical aortic valve, J Thorac Cardiovasc Surg, 2010;140(4):897–903 [Epub 2010 Apr 14].
8. Kahlert P, Knipp SC, Schlamann M, et al., Silent and apparent cerebral ischemia after percutaneous transfemoral aortic valve implantation: a diffusion-weighted magnetic resonance imaging study, Circulation, 2010;121(7):870–8.
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