Probiotics and Helicobacter pylori
5.2–8.3; p<0.01), which became markedly evident at the end of follow- up (3.2±2, 95% CI 2.4–4 versus 5.8±3.4, 95% CI 4.8–6.9; p<0.009). In summary, children receiving L. reuteri complained of epigastric pain less frequently during eradicating treatment (15 versus 45%; p<0.04) as well as abdominal distension (0 versus 25%; p<0.02), belching (5 versus 35%; p<0.04), disorders of defecation (15 versus 45%; p<0.04) and halitosis (5 versus 35%; p<0.04) thereafter.
Subsequently, further trials have been conducted in children showing that the occurrence of antibiotic-associated side effects was significantly reduced by the addition of S. boulardii (8.3 versus 30.9%; p=0.047),81
while the supplementation of standard triple therapy with
L. rhamnosus GG did not significantly alter the incidence of antibiotic associated side effects (52.9 versus 40.6%; p=NS).82
Thus, results showed a positive probiotic impact on overall H. pylori therapy
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