Clinical and Biological Prognostic Markers in Crohn’s Disease
suffered a relapse were higher than in non-relapsing patients (p<0.001) and relapse risk was higher in patients with high FC concentrations and a positive FL.75
Summary and Conclusion
CD represents a heterogeneous entity and the rate at which a patient progresses to complicated disease varies significantly. Accordingly, the ability to predict which patients are likely to develop complicated disease at the time of diagnosis is essential for informing patients about their potential prognosis, closer follow-up of patients at risk, and, importantly, trying to modify disease course with more robust treatment strategies. This has become particularly important over the past decade with the increasing use of biological and immunomodulator therapies.
Although the early use of these therapies might modify disease course, decrease hospitalizations, prevent surgeries, and decrease the need for steroid treatment,12–14
they may be associated with significant side effects and are expensive. Importantly, they may not be needed for the
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