Area Decontamination – Safeguarding Patient Health The hydroxyl free radical, being highly reactive, can attack membrane
lipids, DNA and other essential cell components. H2O2 decontamination systems have proven to be highly effective against pathogens of key concern in a healthcare environment and have been deemed effective for both preventative use and also as part of an outbreak control programme.
The GLOSAIR™ Area Decontamination System The GLOSAIR Area Decontamination System (see Figure 1) was developed for regular use as part of an infection prevention programme. It provides a safe, effective and convenient method for the control of environmental pathogens when used in conjunction with traditional manual cleaning methods. The system can be used to decontaminate small (10 m3) to large (200 m3) spaces,14 practical choice for healthcare facilities.
Figure 1: The GLOSAIR™ 400 System Provides a Safe, Effective and Convenient Method for the Control of Environmental Pathogens
making it a
The GLOSAIR solution contains a low concentration (5–6 %) of H2O2, making it a safe but effective method for area decontamination. It also contains silver cations that contribute to inactivatation by inhibition
of protein synthesis. The unique combination of H202 and silver cations provides an effective dual mechanism for the destruction of microorganisms. The GLOSAIR solution is provided in cartridges that lock
into place without exposing hospital staff to H2O2. A patented nozzle produces a mist of droplets that diffuse uniformly to decontaminate hard-to-reach and hidden areas without leaving wet residues.
The effectiveness of GLOSAIR has been demonstrated in a number of independent field studies against bacteria, fungi and spores, producing log kills of ≥5, 4 or 3, respectively,13
which meets the needs of most
hospital facilities. In the field, GLOSAIR has proven to be effective against a broad range of pathogens, including A. baumannii, moulds, MRSA, Pseudomonas aeruginosa, Mycobacterium tuberculosis and Enterobacter aerogenes.3,15
A brief summary of seven published reports follows. Barbut16 – The study (see Figure 2) was conducted to compare with
0.5 % hypochlorite solution the effectiveness of the GLOSAIR 400 system against C. difficile. The researchers found a 50 % contamination reduction with hypochlorite solution compared with a 91 % reduction following exposure to a GLOSAIR decontamination cycle (see Figure 3). The study concluded that GLOSAIR was significantly more effective than 0.5 % hypochlorite solution at reducing C. difficile contamination.
Shapey17 – Effectiveness of the GLOSAIR 400 system was evaluated
against environmental C. difficile contamination in rooms typically used by elderly patients. The study (see Figure 2) concluded that GLOSAIR had significantly reduced C. difficile contamination in the elder care rooms.
Marty3
– This hospital-based study (see Figure 3) compared the effectiveness of GLOSAIR 400 with manual decontamination. The study concluded that GLOSAIR reduced the total flora better than quaternary ammonium compounds and the system had eradicated A. baumanni following an HAI outbreak.
Andersen18
– Carriers inoculated with Bacillus atrophaeus spores were seeded in closed test rooms. Andersen concluded the GLOSAIR 400 system had good sporicidal effect when used in rooms and other areas.
– The researchers evaluated the effectiveness of the GLOSAIR 400 system in a laboratory contaminated with M. tuberculosis. Mycobacterium reductions greater than 5-logs were reported.
Grare19 EUROPEAN INFECTIOUS DISEASE
30 25 20 15 10 5 0
Shapey et al., 2008 % C. difficile before decontamination
Figure 2: Clostridium Difficile Reduction Using the GLOSAIR™ 400 System
Barbut et al., 2009 % C. difficile after decontamination
Significant reduction in Clostridum difficile achieved by GLOSAIR™ 400 System in two independent field trials.
GLOSAIR was judged to be a safe and effective alternative to the traditional formaldehyde decontamination process.
– Effectiveness of the GLOSAIR 400 system against MRSA was evaluated in a hospital setting. Test results demonstrated effective reductions in MRSA contamination of furniture.
Bartels20 Roques21
– This study evaluated the effectiveness of the GLOSAIR 400 system against VRE. The study was divided into in situ and in vitro portions. Test design included samples of both polyvinyl chloride (PVC) and inox (stainless steel) inoculated with Enterococcus faecium, placed in a hospital room, and exposed to the GLOSAIR process.
119
% positive C. difficile samples
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