Evidence for Anti-vascular Endothelial Growth Factor Treatment of Diabetic Macular Oedema Conclusions
VEGF plays a key role in promoting angiogenesis and vascular leakage and today represents an attractive candidate as a therapeutic target in the treatment and management of diabetic retinopathy. The advent of intravitreal anti-VEGF drugs has opened a new era for the management of DME. While focal/grid laser remains a standard treatment for DME and is supported by evidence provided by large-scale studies,51
of anti-VEGF substances in clinical practice has showed encouraging results. Most of the studies reported in this article were well-designed clinical trials with the objective of demonstrating both the therapeutic effect of anti-VEGF drugs and data regarding their safety. However, only larger trials can consolidate the use of anti-VEGF drugs in the clinical routine with the objective of creating guidelines for the management of DME. Another aspect that must be highlighted is the efficacy of anti-VEGF drugs over longer follow-up periods. Most controlled studies focus on one- or two-year results, but long-term results are unavailable. It would be of the utmost importance to demonstrate that anti-VEGF
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