Fifty Years of Progress Against Cancer
For example, EORTC trial 22981/26981 led to a global platform of four large Phase III trials in patients with brain tumours, and involved EORTC, the Radiation Therapy Oncology Group, the North Central Cancer Treatment Group and the National Cancer Institute of Canada. The MINDACT trial, for patients with breast cancer, is co-ordinated by EORTC and run under the BIG/TRANSBIG networks. It aims to provide confirmatory evidence that patients with a low recurrence risk signature (obtained using MammaPrint: Agendia; Irvine, CA) may be spared chemotherapy and its burdensome side effects without negative repercussions on survival rates. MINDACT involves sites in the Netherlands, France, Germany, Belgium, Spain, Italy, the UK, Slovenia and Switzerland, and has recruited over 6,600 patients in 111 institutions. The first results are expected in approximately three years.
Looking Forward
Over the past 50 years, EORTC research has resulted in new benchmark treatments for patients with cancer. The organisation plans to continue to further its mission to develop, conduct,
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coordinate and stimulate translational and clinical research in Europe to improve the management of cancer and related problems by increasing survival rates and patient QoL.
Further therapeutic advances will most likely arise from a clinical trial platform that incorporates strong translational research, imaging, biobanking, quality assurance in radiotherapy and in surgery, and research studies aimed at understanding the biology of the disease. This will lead to the development of specific treatments for a fragmented disease that was previously seen as a single entity.
This effort will involve the formation of partnerships with a variety of stakeholders, certainly with other academic groups and learned societies, but also patient organisations, cancer leagues, regulatory agencies and the pharmaceutical industry. In this way, EORTC will ensure that it continues to provide improved treatments for patients with cancer. n
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21. Mandelli F, Vignetti M, Suciu S, et al., Daunorubicin versus mitoxantrone versus idarubicin as induction and consolidation chemotherapy for adults with acute myeloid leukemia: The EORTC and GIMEMA groups study AML-10, J Clin Oncol, 2009;27:5397–403.
22. Eggermont AMM, Suciu S, Santinami M, et al. for the EORTC Melanoma Group. Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: Final results of EORTC 18991, a randomised phase III trial, Lancet, 2008;372:117–26.
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