US Neurology Volume 7 • Issue 2 • Winter 2011


Cover image: MRI Brain Scan. © haydenbird/www.istockphoto.com


Managing Editor Tami Hughes


Sub-editorial Manager Lisa Glass


Senior Sub-editor Jon Billinge


Technical Editors James Gilbart Janet Manson


Design Manager Jennifer Rowley


Junior Designer Tatiana Hall


Production Manager Louise Monrose


Senior Production Co-ordinator Anthony Gibbons


Key Account Director Tim Sheldrick


Medical Sales Director Barney Kent


Marketing Director Sergei Sollo


Publishing Director Cathy Peck


Editorial Contact Tami Hughes


T: +44 (0) 20 7452 5232 F: +44 (0) 20 7452 5050


E: tami.hughes@touchbriefings.com


Circulation Contact Miriam Oppenheim


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Sales Contact Tim Sheldrick


T: +44 (0) 20 7452 5182 F: +44 (0) 20 7452 5606


E: tim.sheldrick@touchbriefings.com


Association Contact Aarti Sharma


T: +44 (0) 20 7452 5330 F: +44 (0) 20 7452 5606


E: aarti.sharma@touchbriefings.com


US Neurology acknowledges the financial assistance of the following companies in the publication of this edition: Bioness Inc., Compumedics USA Inc., Genzyme Corporation, Nautilus Neurosciences Inc., and Teva Neuroscience.


Published by Touch Briefings. Touch Briefings is the trading name of Touch Briefings, a Touch Group plc company.


All information obtained by Touch Briefings and each of the contributors from various sources is as current and accurate as possible. However, due to human or mechanical errors, Touch Briefings and the contributors cannot guarantee the accuracy, adequacy or completeness of any information, and cannot be held responsible for any errors or omissions, or for the results obtained from the use thereof.


Where opinion is expressed, it is that of the authors and does not necessarily coincide with the editorial views of Touch Briefings. Statistical and financial data in this publication have been compiled on the basis of factual information and do not constitute any investment advertisement or investment advice.


www.touchbriefings.com ©2011 All rights reserved ISSN 1758-4000


Francois Bethoux, MD Director, Rehabilitation Services, Mellen Center for Multiple Sclerosis, The Cleveland Clinic


John B Bodensteiner, MD Professor, Pediatrics and Neurology, University of Arizona College of Medicine


Jeffrey L Cummings, MD Director, Cleveland Clinic Lou Ruvo Center for Brain Health


Gary Cutter, PhD Professor of Biostatistics, University of Alabama at Birmingham


Robert M Friedlander, MD Professor and Chairman, Neurological Surgery, University of Pittsburgh


William Friedman, MD Professor and Chairman, Department of Neurosurgery, University of Florida


Anthony J Furlan, MD Professor and Chairman, Department of Neurology, Case Western Reserve University


Vincent Gattullo


Executive Committee, American Parkinson's Disease Association


Peter J Goadsby, MD


Professor of Neurology, University of California, San Francisco


James C Grotta, MD


Professor of Neurology, University of Texas Medical School at Houston


David A Hafler, MD Professor of Neurology, Yale School of Medicine


Editorial Board Daniel F Hanley, MD


Professor, Acute Care Neurology, Johns Hopkins University


Rosalind Kalb, PhD Vice President, Professional Resource Center, National Multiple Sclerosis Society


Carlos S Kase, MD Chief of Neurology, Boston University School of Medicine


John J Kelly, MD Professor of Neurology, George Washington University


Ruben I Kuzniecky, MD Professor and Co-Director, NYU Comprehensive Epilepsy Center


Fred D Lublin, MD


Saunders Family Professor of Neurology, Mount Sinai School of Medicine


Laura Marsh, MD


Head, Mental Health Care Line, Michael E DeBakey VA Medical Center


Michael S Okun, MD


Co-director, University of Florida Movement Disorders Center, McKnight Brain Institute


C Warren Olanow, MD Professor, Department of Neurology, Mount Sinai School of Medicine


George Perry, PhD


Dean and Professor, College of Sciences, University of Texas at San Antonio


George B Richerson, MD, PhD Professor and Chairman, Neurology, University of Iowa


Donald Schomer, MD


Professor of Neurology, Beth Israel Deaconess Medical Center, and Harvard Medical School


Steven S Schreiber, MD Professor, Department of Neurology, University of California, Irvine


Michael Schulder, MD Associate Professor of


Neurosurgery, University Hospital, New Jersey Medical School


Stephen D Silberstein, MD Professor of Neurology, Jefferson Headache Center


Stewart J Tepper, MD Professor, Center for Headache and Pain, Cleveland Clinic


Arthur Toga, PhD


Professor of Neurology, Laboratory of Neuro Imaging, University of California, Los Angeles


Steven U Walkley, DVM, PhD Professor, Neuroscience, Pathology, and Neurology, Albert Einstein College of Medicine


Cheryl Waters, MD, FRCP(C) Professor, Division of Movement Disorders, Columbia University Medical Center


William J Weiner, MD Professor and Chairman of Neurology, University of Maryland


Patrick Y Wen, MD Neuro-oncologist, Dana Farber/Brigham and Women’s Cancer Center


G Frederick Wooten, MD Professor and Chairman, Department of Neurology, University of Virginia


US Neurology wishes to thank the organizations below for their assistance. This does not constitute any official endorsement.


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