Estimating Glomerular Filtration Rate in 2012
Table 2: Summary of Studies Comparing the Performance of the Modification of Diet in Renal Disease Study and Chronic Kidney Disease Epidemiology Equation
Reference
Michels et al., 201035
Tent et al., 201036
Patient Population Sample and Number
Kidney donors and
diverse CKD patients n=271 Donors before and after donation n=253
mGFR Iothalamate Iothalamate GFR Range (ml/min/1.73 m2 73±30 Before
103 ± 15 After
66 ± 11
Lane et al., 201032
Cirillo et al., 201028
Soares et al., 201029
White et al., 201040
Kukla et al., 201042
Patients before (n=268) and after (n=157) nephrectomy n=425
Diverse sample including healthy subjects (n=182) n=356
Healthy subjects n=69
Renal transplant patients n=207
Renal transplant,
steroid-free patients n=107
Bargnoux et al., Renal transplant patients 201241
n=85
Pöge et al., 201143
Buron et al., 201144
Orskov et al., 201030
Eriksen et al., 201033
Nyman et al., 201134
Iliadis et al., 201131
Silveiro et al., 201139
Nair et al., 201137
Tent et al., 201165
Redal-Baigorri et al., 201166 Murata et al., 201145
Renal transplant patients n=170
Renal transplant patients n=1,249
ADPK patients n=101
General, healthy
population n=1,621 Patients referred for
GFR measurement n=850 Type 2 diabetics n=448
Type 2 diabetics n=105
Type 2 diabetics n=111
Non-diabetic CKD patients n=65 Cancer patients n=185
Kidney donors (n=583)
Donors after donation (n=97)
CKD patients (n=2,324)
Renal transplant patients (n=1,375)
Non-kidney transplant patients (n=859) n=5,238
99Tc DTPA Inulin 51Cr EDTA Iohexol Iohexol 51Cr EDTA 51Cr EDTA 51Cr EDTA Iothalamate Cr EDTA51 Iothalamate 54 ± 18 99Tc DTPA 53 ± 21 Iothalamate Inulin 51Cr EDTA 99Tc DTPA Iothalamate 50 (IQR: 29–69)* 72 ± 36 112 ± 24 58 ± 22 56 ± 17 ) Bias
(ml/min/1.73 m2 or in % if given) M: +25
C: +17
Before* M: -22 C: -14 After
M: -15 C: -11 M: -1* C: -1.7
M: -5 C: -0.9
M: -18 C: -10 M: -8 C: -5
M: +8 C: +13
M: -4 C: 0
40 (RANGE: 12–83) M: +4 C: +7
M: -0.5 C: +3.9
64 (RANGE: 7–118) M: -5 C: -11
92 ± 14 55 (5–223)* 73 ± 23 103 ± 23 84 ± 39 78 ± 27 85 ± 20 45 ± 12 53 ± 11 60 ± 15 54 ± 14 57 ± 12 56 ± 30
M: +1.3* C: +2.9
M: +1.2* C: +2.3 M: +8 C: +7
M: -20 C: -24 M: -6 C: -24
M: -15* C: -8
M: +1 C: -1
M: -18 % C: -8 %
M: -15 % C: -7 % M: +3 % C: +6 % M: +1 % C: +8 % M: +3 % C: +9 % NA NA
Precision (ml/min/1.73 m2
M: 15 C: 12
Before* M: 20 C: 18 After M: 12 C: 12
M: 15* C: 14
M: 15 C: 13
M: 26 C: 24 M: 12 C: 13 M: 16 C: 16
M: 14 C: 15 M: 10 C: 11 M: 12 C: 13 M: 10 C: 10
M: 18* C: 15
M: 14* C: 14 M: 13 C: 12 M: 22 C: 21 NA
M: 22* C: 21 M: 16 C: 13 NA
Accuracy
) 30 % (%)
M: 81 C: 85
Before M: 73 C: 89 After M: 71 C: 89 M: 75 C: 80
M: 87 C: 88
M: 69 C: 85 M: 79 C: 84 M: 72 C: 59
M: 73 C: 83 M: 72 C: 64 M: 85 C: 81 M: 90 C: 83 M: 93 C: 95 M: 80 C: 80 M: 79 C: 81 M: 67 C: 64 NA
M: 77 C: 82 M: 89 C: 90 M: 76 C: 89 M: 83 C: 94 M: 75 C: 75 M: 80 C: 78 M: 81 C: 79 M: 78 C: 78
ADPK = autosomal dominant polycystic kidney disease; CKD = chronic kidney disease; CKD-EPI = Chronic Kidney Disease Epidemiology; Cr EDTA = ethylenediaminetetra-acetic acid; GFR = glomerular filtration rate; MDRD study = Modification of diet in renal disease study; NA = not available; Tc DPTA = diethylenetriaminepenta-acetic acid. * If bias is median difference and precision is interquartile range (IQR); M: MDRD study equation; C: CKD-EPI equation; bias is the mean difference between estimated GFR (eGFR) and measured GFR (mGFR); precision is the standard deviation around the mean difference; accuracy 30 % is the percentage of subjects with eGFR within ±30 % of measured GFR.
EUROPEAN NEPHROLOGY
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